MIT Libraries logoDSpace@MIT

MIT
View Item 
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Early detection of high-grade squamous intraepithelial lesions in the cervix with quantitative spectroscopic imaging

Author(s)
Lau, Condon; Mirkovic, Jelena; Yu, Chung-Chieh; O'Donoghue, Geoff P.; Galindo, Luis H.; Dasari, Ramachandra Rao; Feld, Michael S.; de las Morenas, Antonio; Stier, Elizabeth; ... Show more Show less
Thumbnail
DownloadLau-2013-Early detection of high-grade squamous intraepithelial lesions.pdf (2.665Mb)
PUBLISHER_POLICY

Publisher Policy

Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.

Terms of use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Metadata
Show full item record
Abstract
Quantitative spectroscopy has recently been extended from a contact-probe to wide-area spectroscopic imaging to enable mapping of optical properties across a wide area of tissue. We train quantitative spectroscopic imaging (QSI) to identify cervical high-grade squamous intraepithelial lesions (HSILs) in 34 subjects undergoing the loop electrosurgical excision procedure (LEEP subjects). QSI’s performance is then prospectively evaluated on the clinically suspicious biopsy sites from 47 subjects undergoing colposcopic-directed biopsy. The results show the per-subject normalized reduced scattering coefficient at 700 nm (A[subscript n]) and the total hemoglobin concentration are significantly different (p<0.05) between HSIL and non-HSIL sites in LEEP subjects. A[subscript n] alone retrospectively distinguishes HSIL from non-HSIL with 89% sensitivity and 83% specificity. It alone applied prospectively on the biopsy sites distinguishes HSIL from non-HSIL with 81% sensitivity and 78% specificity. The findings of this study agree with those of an earlier contact-probe study, validating the robustness of QSI, and specifically A[subscript n], for identifying HSIL. The performance of A[subscript n] suggests an easy to use and an inexpensive to manufacture monochromatic instrument is capable of early cervical cancer detection, which could be used as a screening and diagnostic tool for detecting cervical cancer in low resource countries.
Date issued
2013-07
URI
http://hdl.handle.net/1721.1/80302
Department
Massachusetts Institute of Technology. Department of Chemistry; Massachusetts Institute of Technology. Spectroscopy Laboratory
Journal
Journal of Biomedical Optics
Publisher
SPIE
Citation
Lau, Condon. “Early detection of high-grade squamous intraepithelial lesions in the cervix with quantitative spectroscopic imaging.” Journal of Biomedical Optics 18, no. 7 (July 1, 2013): 076013. © 2013 Society of Photo-Optical Instrumentation Engineers
Version: Final published version
ISSN
1083-3668
1560-2281

Collections
  • MIT Open Access Articles

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

Login

Statistics

OA StatisticsStatistics by CountryStatistics by Department
MIT Libraries
PrivacyPermissionsAccessibilityContact us
MIT
Content created by the MIT Libraries, CC BY-NC unless otherwise noted. Notify us about copyright concerns.