dc.contributor.author | Lau, Condon | |
dc.contributor.author | Mirkovic, Jelena | |
dc.contributor.author | Yu, Chung-Chieh | |
dc.contributor.author | O'Donoghue, Geoff P. | |
dc.contributor.author | Galindo, Luis H. | |
dc.contributor.author | Dasari, Ramachandra Rao | |
dc.contributor.author | Feld, Michael S. | |
dc.contributor.author | de las Morenas, Antonio | |
dc.contributor.author | Stier, Elizabeth | |
dc.date.accessioned | 2013-08-27T16:05:58Z | |
dc.date.available | 2013-08-27T16:05:58Z | |
dc.date.issued | 2013-07 | |
dc.date.submitted | 2013-05 | |
dc.identifier.issn | 1083-3668 | |
dc.identifier.issn | 1560-2281 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/80302 | |
dc.description.abstract | Quantitative spectroscopy has recently been extended from a contact-probe to wide-area spectroscopic imaging to enable mapping of optical properties across a wide area of tissue. We train quantitative spectroscopic imaging (QSI) to identify cervical high-grade squamous intraepithelial lesions (HSILs) in 34 subjects undergoing the loop electrosurgical excision procedure (LEEP subjects). QSI’s performance is then prospectively evaluated on the clinically suspicious biopsy sites from 47 subjects undergoing colposcopic-directed biopsy. The results show the per-subject normalized reduced scattering coefficient at 700 nm (A[subscript n]) and the total hemoglobin concentration are significantly different (p<0.05) between HSIL and non-HSIL sites in LEEP subjects. A[subscript n] alone retrospectively distinguishes HSIL from non-HSIL with 89% sensitivity and 83% specificity. It alone applied prospectively on the biopsy sites distinguishes HSIL from non-HSIL with 81% sensitivity and 78% specificity. The findings of this study agree with those of an earlier contact-probe study, validating the robustness of QSI, and specifically A[subscript n], for identifying HSIL. The performance of A[subscript n] suggests an easy to use and an inexpensive to manufacture monochromatic instrument is capable of early cervical cancer detection, which could be used as a screening and diagnostic tool for detecting cervical cancer in low resource countries. | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (Massachusetts Institute of Technology. Laser Biomedical Research Center Grant R01 CA097966) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (Massachusetts Institute of Technology. Laser Biomedical Research Center Grant P41 RR02594) | en_US |
dc.language.iso | en_US | |
dc.publisher | SPIE | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1117/1.jbo.18.7.076013 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | SPIE | en_US |
dc.title | Early detection of high-grade squamous intraepithelial lesions in the cervix with quantitative spectroscopic imaging | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Lau, Condon. “Early detection of high-grade squamous intraepithelial lesions in the cervix with quantitative spectroscopic imaging.” Journal of Biomedical Optics 18, no. 7 (July 1, 2013): 076013. © 2013 Society of Photo-Optical Instrumentation Engineers | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Spectroscopy Laboratory | en_US |
dc.contributor.mitauthor | Lau, Condon | en_US |
dc.contributor.mitauthor | Mirkovic, Jelena | en_US |
dc.contributor.mitauthor | Yu, Chung-Chieh | en_US |
dc.contributor.mitauthor | O'Donoghue, Geoff P. | en_US |
dc.contributor.mitauthor | Galindo, Luis H. | en_US |
dc.contributor.mitauthor | Dasari, Ramachandra Rao | en_US |
dc.contributor.mitauthor | Feld, Michael S. | en_US |
dc.relation.journal | Journal of Biomedical Optics | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Lau, Condon | en_US |
dc.identifier.orcid | https://orcid.org/0000-0003-3313-6257 | |
dspace.mitauthor.error | true | |
mit.license | PUBLISHER_POLICY | en_US |
mit.metadata.status | Complete | |