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Repressive Transcription

Author(s)
Guenther, Matthew G.; Young, Richard A.
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Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/
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Abstract
How are active and repressed portions of the genome established and maintained during development? In vertebrates, about 2 m of DNA is packaged into chromatin in a manner that allows for active transcription of some loci and repression of others. Most chromatin regulators do not recognize specific DNA sequences, so how are they recruited to specific sites throughout the genome? For actively transcribed genes, transcription factors or the transcription initiation apparatus recruit regulators associated with active chromatin (1). For genes that are repressed, recent studies suggest a counterintuitive model: Transcription initiates the formation of repressive chromatin (2–9).
Description
2011 July 9 Author Manuscript
Date issued
2010-07
URI
http://hdl.handle.net/1721.1/81257
Department
Massachusetts Institute of Technology. Department of Biology; Whitehead Institute for Biomedical Research
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Guenther, M. G., and R. A. Young. “Repressive Transcription.” Science 329, no. 5988 (July 8, 2010): 150-151.
Version: Author's final manuscript
ISSN
0036-8075
1095-9203

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