Surface modification of a polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane (POSS-PCU) nanocomposite polymer as a stent coating for enhanced capture of endothelial progenitor cells
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1559-4106-8-23.pdf
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5.03 MB
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Checksum (MD5)
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Author(s)
Tan, Aaron
Farhatnia, Yasmin
Goh, Debbie
G, Natasha
de Mel, Achala
Lim, Jing
Teoh, Swee-Hin
Malkovskiy, Andrey V
Chawla, Reema
Rajadas, Jayakumar
Date Issued
August 2013
Journal
Biointerphases
Publisher
Springer-Verlag
Citation
Tan, Aaron et al. “Surface Modification of a Polyhedral Oligomeric Silsesquioxane Poly(carbonate-urea) Urethane (POSS-PCU) Nanocomposite Polymer as a Stent Coating for Enhanced Capture of Endothelial Progenitor Cells.” Biointerphases 8.1 (2013): 23.
Version
Final published version
Abstract
An unmet need exists for the development of next-generation multifunctional nanocomposite materials for biomedical applications, particularly in the field of cardiovascular regenerative biology. Herein, we describe the preparation and characterization of a novel polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane (POSS-PCU) nanocomposite polymer with covalently attached anti-CD34 antibodies to enhance capture of circulating endothelial progenitor cells (EPC). This material may be used as a new coating for bare metal stents used after balloon angioplasty to improve re-endothelialization. Biophysical characterization techniques were used to assess POSS-PCU and its subsequent functionalization with anti-CD34 antibodies. Results indicated successful covalent attachment of anti-CD34 antibodies on the surface of POSS-PCU leading to an increased propensity for EPC capture, whilst maintaining in vitro biocompatibility and hemocompatibility. POSS-PCU has already been used in 3 first-in-man studies, as a bypass graft, lacrimal duct and a bioartificial trachea. We therefore postulate that its superior biocompatibility and unique biophysical properties would render it an ideal candidate for coating medical devices, with stents as a prime example. Taken together, anti-CD34 functionalized POSS-PCU could form the basis of a nano-inspired polymer platform for the next generation stent coatings.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
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DOI of Published Version
https://doi.org/10.1186/1559-4106-8-23
