dc.contributor.author | Tan, Aaron | |
dc.contributor.author | Farhatnia, Yasmin | |
dc.contributor.author | Goh, Debbie | |
dc.contributor.author | G, Natasha | |
dc.contributor.author | de Mel, Achala | |
dc.contributor.author | Lim, Jing | |
dc.contributor.author | Teoh, Swee-Hin | |
dc.contributor.author | Malkovskiy, Andrey V | |
dc.contributor.author | Chawla, Reema | |
dc.contributor.author | Rajadas, Jayakumar | |
dc.contributor.author | Cousins, Brian G | |
dc.contributor.author | Alavijeh, Mohammad S | |
dc.contributor.author | Seifalian, Alexander M | |
dc.contributor.author | Hamblin, Michael R. | |
dc.date.accessioned | 2013-10-21T12:16:30Z | |
dc.date.available | 2013-10-21T12:16:30Z | |
dc.date.issued | 2013-08 | |
dc.date.submitted | 2013-06 | |
dc.identifier.issn | 1559-4106 | |
dc.identifier.issn | 1934-8630 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/81439 | |
dc.description.abstract | An unmet need exists for the development of next-generation multifunctional nanocomposite materials for biomedical applications, particularly in the field of cardiovascular regenerative biology. Herein, we describe the preparation and characterization of a novel polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane (POSS-PCU) nanocomposite polymer with covalently attached anti-CD34 antibodies to enhance capture of circulating endothelial progenitor cells (EPC). This material may be used as a new coating for bare metal stents used after balloon angioplasty to improve re-endothelialization. Biophysical characterization techniques were used to assess POSS-PCU and its subsequent functionalization with anti-CD34 antibodies. Results indicated successful covalent attachment of anti-CD34 antibodies on the surface of POSS-PCU leading to an increased propensity for EPC capture, whilst maintaining in vitro biocompatibility and hemocompatibility. POSS-PCU has already been used in 3 first-in-man studies, as a bypass graft, lacrimal duct and a bioartificial trachea. We therefore postulate that its superior biocompatibility and unique biophysical properties would render it an ideal candidate for coating medical devices, with stents as a prime example. Taken together, anti-CD34 functionalized POSS-PCU could form the basis of a nano-inspired polymer platform for the next generation stent coatings. | en_US |
dc.publisher | Springer-Verlag | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1186/1559-4106-8-23 | en_US |
dc.rights | Creative Commons Attribution | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/2.0 | en_US |
dc.source | BMC | en_US |
dc.title | Surface modification of a polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane (POSS-PCU) nanocomposite polymer as a stent coating for enhanced capture of endothelial progenitor cells | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Tan, Aaron et al. “Surface Modification of a Polyhedral Oligomeric Silsesquioxane Poly(carbonate-urea) Urethane (POSS-PCU) Nanocomposite Polymer as a Stent Coating for Enhanced Capture of Endothelial Progenitor Cells.” Biointerphases 8.1 (2013): 23. | en_US |
dc.contributor.department | Harvard University--MIT Division of Health Sciences and Technology | en_US |
dc.contributor.mitauthor | Hamblin, Michael R. | en_US |
dc.relation.journal | Biointerphases | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dc.date.updated | 2013-10-17T08:12:01Z | |
dc.language.rfc3066 | en | |
dc.rights.holder | Aaron Tan et al.; licensee BioMed Central Ltd. | |
dspace.orderedauthors | Tan, Aaron; Farhatnia, Yasmin; Goh, Debbie; G, Natasha; de Mel, Achala; Lim, Jing; Teoh, Swee-Hin; Malkovskiy, Andrey V; Chawla, Reema; Rajadas, Jayakumar; Cousins, Brian G; Hamblin, Michael R; Alavijeh, Mohammad S; Seifalian, Alexander M | en_US |
mit.license | PUBLISHER_CC | en_US |
mit.metadata.status | Complete | |