Show simple item record

dc.contributor.authorTan, Aaron
dc.contributor.authorFarhatnia, Yasmin
dc.contributor.authorGoh, Debbie
dc.contributor.authorG, Natasha
dc.contributor.authorde Mel, Achala
dc.contributor.authorLim, Jing
dc.contributor.authorTeoh, Swee-Hin
dc.contributor.authorMalkovskiy, Andrey V
dc.contributor.authorChawla, Reema
dc.contributor.authorRajadas, Jayakumar
dc.contributor.authorCousins, Brian G
dc.contributor.authorAlavijeh, Mohammad S
dc.contributor.authorSeifalian, Alexander M
dc.contributor.authorHamblin, Michael R.
dc.date.accessioned2013-10-21T12:16:30Z
dc.date.available2013-10-21T12:16:30Z
dc.date.issued2013-08
dc.date.submitted2013-06
dc.identifier.issn1559-4106
dc.identifier.issn1934-8630
dc.identifier.urihttp://hdl.handle.net/1721.1/81439
dc.description.abstractAn unmet need exists for the development of next-generation multifunctional nanocomposite materials for biomedical applications, particularly in the field of cardiovascular regenerative biology. Herein, we describe the preparation and characterization of a novel polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane (POSS-PCU) nanocomposite polymer with covalently attached anti-CD34 antibodies to enhance capture of circulating endothelial progenitor cells (EPC). This material may be used as a new coating for bare metal stents used after balloon angioplasty to improve re-endothelialization. Biophysical characterization techniques were used to assess POSS-PCU and its subsequent functionalization with anti-CD34 antibodies. Results indicated successful covalent attachment of anti-CD34 antibodies on the surface of POSS-PCU leading to an increased propensity for EPC capture, whilst maintaining in vitro biocompatibility and hemocompatibility. POSS-PCU has already been used in 3 first-in-man studies, as a bypass graft, lacrimal duct and a bioartificial trachea. We therefore postulate that its superior biocompatibility and unique biophysical properties would render it an ideal candidate for coating medical devices, with stents as a prime example. Taken together, anti-CD34 functionalized POSS-PCU could form the basis of a nano-inspired polymer platform for the next generation stent coatings.en_US
dc.publisherSpringer-Verlagen_US
dc.relation.isversionofhttp://dx.doi.org/10.1186/1559-4106-8-23en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_US
dc.sourceBMCen_US
dc.titleSurface modification of a polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane (POSS-PCU) nanocomposite polymer as a stent coating for enhanced capture of endothelial progenitor cellsen_US
dc.typeArticleen_US
dc.identifier.citationTan, Aaron et al. “Surface Modification of a Polyhedral Oligomeric Silsesquioxane Poly(carbonate-urea) Urethane (POSS-PCU) Nanocomposite Polymer as a Stent Coating for Enhanced Capture of Endothelial Progenitor Cells.” Biointerphases 8.1 (2013): 23.en_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.mitauthorHamblin, Michael R.en_US
dc.relation.journalBiointerphasesen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2013-10-17T08:12:01Z
dc.language.rfc3066en
dc.rights.holderAaron Tan et al.; licensee BioMed Central Ltd.
dspace.orderedauthorsTan, Aaron; Farhatnia, Yasmin; Goh, Debbie; G, Natasha; de Mel, Achala; Lim, Jing; Teoh, Swee-Hin; Malkovskiy, Andrey V; Chawla, Reema; Rajadas, Jayakumar; Cousins, Brian G; Hamblin, Michael R; Alavijeh, Mohammad S; Seifalian, Alexander Men_US
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record