Rhodium-Catalyzed Asymmetric Intramolecular Hydroamination of Unactivated Alkenes

Author(s)
Shen, Xiaoqiang; Buchwald, Stephen Leffler
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Abstract
One for the Rh(oad): The first rhodium-catalyzed asymmetric intramolecular hydroamination of unactivated olefins was developed by using dialkylbiaryl phosphine ligands (see scheme; cod=1,5-cyclooctadiene, Cy=cyclohexyl). A variety of 2-methylpyrrolidines have been synthesized with high enantioselectivities.
Date issued
2009-12
URI
http://hdl.handle.net/1721.1/81938
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Shen, Xiaoqiang, and Stephen L. Buchwald. “Rhodium-Catalyzed Asymmetric Intramolecular Hydroamination of Unactivated Alkenes.” Angewandte Chemie International Edition 49, no. 3 (January 12, 2010): 564-567.
Version: Author's final manuscript
ISSN
14337851
1521-3773
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