Palladium(0)-Catalyzed Arylative Dearomatization of Phenols

Author(s)
Rousseaux, Sophie; Garcia-Fortanet, Jorge; Del Aguila Sanchez, Miguel Angel; Buchwald, Stephen Leffler
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Abstract
The palladium-catalyzed arylative dearomatization of phenols to yield spirocyclohexadienone products in good to excellent yields has been developed. Preliminary results demonstrate that the formation of the spirocyclic all-carbon quaternary center can be accomplished with high levels of enantiocontrol (up to 91% ee).
Date issued
2011-05
URI
http://hdl.handle.net/1721.1/81941
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Citation
Rousseaux, Sophie, Jorge Garcia-Fortanet, Miguel Angel Del Aguila Sanchez, and Stephen L. Buchwald. “Palladium(0)-Catalyzed Arylative Dearomatization of Phenols.” Journal of the American Chemical Society 133, no. 24 (June 22, 2011): 9282-9285.
Version: Author's final manuscript
ISSN
0002-7863
1520-5126
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