Iron(II)-Catalyzed Trifluoromethylation of Potassium Vinyltrifluoroborates

Author(s)
Parsons, Andrew T.; Senecal, Todd D.; Buchwald, Stephen Leffler
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Abstract
Exchanging BF[subscript 3] by CF[subscript 3]: The title reaction proceeds under exceedingly mild reaction conditions and provides 2-arylvinyl- and 2-heteroarylvinyl-substituted substrates with E/Z selectivities of more than 95:5. Experimental observations suggest that the reaction does not proceed through a transmetalation of the RBF[subscript 3]K species to the iron catalyst.
Date issued
2012-02
URI
http://hdl.handle.net/1721.1/81943
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Parsons, Andrew T., Todd D. Senecal, and Stephen L. Buchwald. “Iron(II)-Catalyzed Trifluoromethylation of Potassium Vinyltrifluoroborates.” Angewandte Chemie International Edition 51, no. 12 (March 19, 2012): 2947-2950.
Version: Author's final manuscript
ISSN
14337851
1521-3773
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