Palladium-Catalyzed N-Arylation of 2-Aminothiazoles

Author(s)
McGowan, Meredeth A.; Henderson, Jaclyn L.; Buchwald, Stephen Leffler
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Abstract
A method for the Pd-catalyzed coupling of 2-aminothiazole derivatives with aryl bromides and triflates is described. Significantly, for this class of nucleophiles, the coupling exhibits a broad substrate scope and proceeds with a reasonable catalyst loading. Furthermore, an interesting effect of acetic acid as an additive is uncovered that facilitates catalyst activation.
Date issued
2012-03
URI
http://hdl.handle.net/1721.1/81945
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Organic Letters
Publisher
American Chemical Society (ACS)
Citation
McGowan, Meredeth A., Jaclyn L. Henderson, and Stephen L. Buchwald. “Palladium-Catalyzed N-Arylation of 2-Aminothiazoles.” Organic Letters 14, no. 6 (March 16, 2012): 1432-1435.
Version: Author's final manuscript
ISSN
1523-7060
1523-7052
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