Palladium-Catalyzed N-Arylation of 2-Aminothiazoles
Author(s)McGowan, Meredeth A.; Henderson, Jaclyn L.; Buchwald, Stephen Leffler
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A method for the Pd-catalyzed coupling of 2-aminothiazole derivatives with aryl bromides and triflates is described. Significantly, for this class of nucleophiles, the coupling exhibits a broad substrate scope and proceeds with a reasonable catalyst loading. Furthermore, an interesting effect of acetic acid as an additive is uncovered that facilitates catalyst activation.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
American Chemical Society (ACS)
McGowan, Meredeth A., Jaclyn L. Henderson, and Stephen L. Buchwald. “Palladium-Catalyzed N-Arylation of 2-Aminothiazoles.” Organic Letters 14, no. 6 (March 16, 2012): 1432-1435.
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