Accelerating Palladium-Catalyzed C-F Bond Formation: Use of a Microflow Packed-Bed Reactor
Author(s)Maimone, Thomas; Noel, Timothy; Buchwald, Stephen Leffler
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A flow process for Pd-catalyzed C-F bond formation is described. A microreactor with a packed-bed design allows for easy handling of large quantities of insoluble CsF with precise control over reaction times, efficient mixing, and the ability to safely handle elevated temperatures and pressures. A variety of aryl triflates, including heteroaryl ones, were converted into aryl fluorides in short reaction times (see scheme).
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Angewandte Chemie International Edition
Noël, Timothy, Thomas J. Maimone, and Stephen L. Buchwald. “Accelerating Palladium-Catalyzed C-F Bond Formation: Use of a Microflow Packed-Bed Reactor.” Angewandte Chemie International Edition 50, no. 38 (September 12, 2011): 8900-8903.
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