| dc.contributor.author | Maimone, Thomas | |
| dc.contributor.author | Noel, Timothy | |
| dc.contributor.author | Buchwald, Stephen Leffler | |
| dc.date.accessioned | 2013-11-01T17:02:34Z | |
| dc.date.available | 2013-11-01T17:02:34Z | |
| dc.date.issued | 2011-08 | |
| dc.date.submitted | 2011-07 | |
| dc.identifier.issn | 14337851 | |
| dc.identifier.issn | 1521-3773 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/81946 | |
| dc.description.abstract | A flow process for Pd-catalyzed C-F bond formation is described. A microreactor with a packed-bed design allows for easy handling of large quantities of insoluble CsF with precise control over reaction times, efficient mixing, and the ability to safely handle elevated temperatures and pressures. A variety of aryl triflates, including heteroaryl ones, were converted into aryl fluorides in short reaction times (see scheme). | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Grant GM46059) | en_US |
| dc.description.sponsorship | Fulbright Program (Fellowship) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Postdoctoral Fellowship 1F32GM088931) | en_US |
| dc.description.sponsorship | National Science Foundation (U.S.) (Grant CHE 9808061) | en_US |
| dc.description.sponsorship | National Science Foundation (U.S.) (Grant DBI 9729592) | en_US |
| dc.description.sponsorship | Novartis (Firm) | en_US |
| dc.language.iso | en_US | |
| dc.publisher | Wiley Blackwell | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1002/anie.201104652 | en_US |
| dc.rights | Creative Commons Attribution-Noncommercial-Share Alike 3.0 | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/ | en_US |
| dc.source | PMC | en_US |
| dc.title | Accelerating Palladium-Catalyzed C-F Bond Formation: Use of a Microflow Packed-Bed Reactor | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Noël, Timothy, Thomas J. Maimone, and Stephen L. Buchwald. “Accelerating Palladium-Catalyzed C-F Bond Formation: Use of a Microflow Packed-Bed Reactor.” Angewandte Chemie International Edition 50, no. 38 (September 12, 2011): 8900-8903. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
| dc.contributor.mitauthor | Noel, Timothy | en_US |
| dc.contributor.mitauthor | Maimone, Thomas | en_US |
| dc.contributor.mitauthor | Buchwald, Stephen Leffler | en_US |
| dc.relation.journal | Angewandte Chemie International Edition | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Noël, Timothy; Maimone, Thomas J.; Buchwald, Stephen L. | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0002-3107-6927 | |
| dc.identifier.orcid | https://orcid.org/0000-0003-3875-4775 | |
| dspace.mitauthor.error | true | |
| mit.license | OPEN_ACCESS_POLICY | en_US |
| mit.metadata.status | Complete | |
