Copper-Catalyzed Trifluoromethylation of Unactivated Olefins

Author(s)
Parsons, Andrew T.; Buchwald, Stephen Leffler
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Abstract
Activating the inactive: A copper-catalyzed allylic trifluoromethylation of unactivated terminal olefins proceeds under mild conditions to produce linear allylic trifluoromethylated products with high E/Z selectivity (see scheme). The reaction can be applied to a range of substrates bearing numerous functional groups. Furthermore, the reaction is scalable and amenable to a benchtop setup.
Date issued
2011-08
URI
http://hdl.handle.net/1721.1/81948
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Parsons, Andrew T., and Stephen L. Buchwald. “Copper-Catalyzed Trifluoromethylation of Unactivated Olefins.” Angewandte Chemie International Edition 50, no. 39 (September 19, 2011): 9120-9123.
Version: Author's final manuscript
ISSN
14337851
1521-3773
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