Concise Palladium-Catalyzed Synthesis of Dibenzodiazepines and Structural Analogs
Author(s)Tsvelikhovsky, Dmitry; Buchwald, Stephen Leffler
Concise Palladium-Catalyzed Synthesis of Dibenzodiazepines and Structural Analogues
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A general and highly efficient protocol for the synthesis of dibenzodiazepines and their structural analogues is reported. In the presence of catalytic quantities of palladium, readily accessible precursors are cross-coupled with ammonia and then spontaneously undergo an intramolecular condensation to form the corresponding dibenzodiazepines in one step. This new strategy is applicable to the construction of a wide variety of dibenzooxazepines and other structurally related heterocycles.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Journal of the American Chemical Society
American Chemical Society (ACS)
Tsvelikhovsky, Dmitry, and Stephen L. Buchwald. “Concise Palladium-Catalyzed Synthesis of Dibenzodiazepines and Structural Analogues.” Journal of the American Chemical Society 133, no. 36 (September 14, 2011): 14228-14231.
Author's final manuscript