The Palladium-Catalyzed Trifluoromethylation of Vinyl Sulfonates
Author(s)Cho, Eun Jin; Buchwald, Stephen Leffler
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A method for the palladium-catalyzed trifluoromethylation of cyclohexenyl sulfonates has been developed. Various cyclohexenyl triflates and nonaflates underwent trifluoromethylation under mild reaction conditions using a catalyst system composed of Pd(dba)[subscript 2] or [(allyl)PdCl][subscript 2] and the monodentate biaryl phosphine ligand [superscript t]BuXPhos. The trifluoromethyl anion (CF[– over 3]) or its equivalent for the process was generated in situ from TMSCF[subscript 3] in combination with KF or TESCF[subscript 3] in combination with RbF.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
American Chemical Society (ACS)
Cho, Eun Jin, and Stephen L. Buchwald. “The Palladium-Catalyzed Trifluoromethylation of Vinyl Sulfonates.” Organic Letters 13, no. 24 (December 16, 2011): 6552-6555.
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