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AFB1-induced mutagenesis of the gpt gene in AS52 cells

dc.contributor.authorWattanawaraporn, Roongtiwa
dc.contributor.authorKim, Min Young
dc.contributor.authorAdams, Jillian
dc.contributor.authorTrudel, Laura J.
dc.contributor.authorWoo, Leslie
dc.contributor.authorCroy, Robert G.
dc.contributor.authorEssigmann, John M.
dc.contributor.authorWogan, Gerald N.
dc.date.accessioned2013-11-07T18:08:33Z
dc.date.available2013-11-07T18:08:33Z
dc.date.issued2012-08
dc.date.submitted2012-02
dc.identifier.issn08936692
dc.identifier.issn1098-2280
dc.identifier.urihttp://hdl.handle.net/1721.1/82021
dc.description.abstractAflatoxin B1 (AFB1) is a potent mutagen and an important risk factor for hepatocellular carcinoma (HCC) in humans. Transgenic mouse strains and cells in culture have been used to detect different types of mutations caused by AFB1 and investigate the molecular determinants of their location and frequency. The AFB1 mutational spectrum in the gpt gene was markedly different in AS52 cells compared with the liver in gpt delta B6C3F1 transgenic mice. The results demonstrate the importance of metabolism, chromosomal location, transcription and selection conditions on mutational spectra.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NIH grant R01 ES016313)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NIH grant P30 ES002109)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NIH grant T32 ES007020)en_US
dc.description.sponsorshipChulabhorn Research Institute (Bangkok, Thailand)en_US
dc.language.isoen_US
dc.publisherJohn Wiley & Sons, Inc.en_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/em.21711en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alike 3.0en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.sourceProf. Essigmann via Howard Silveren_US
dc.titleAFB1-induced mutagenesis of the gpt gene in AS52 cellsen_US
dc.typeArticleen_US
dc.identifier.citationWattanawaraporn, Roongtiwa, Min Young Kim, Jillian Adams, Laura J. Trudel, Leslie L. Woo, Robert G. Croy, John M. Essigmann, and Gerald N. Wogan. “AFB1-induced mutagenesis of the gpt gene in AS52 cells.” Environmental and Molecular Mutagenesis 53, no. 7 (August 26, 2012): 567-573.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Center for Environmental Health Sciencesen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.approverEssigmann, John M.en_US
dc.contributor.mitauthorEssigmann, John M.en_US
dc.contributor.mitauthorWattanawaraporn, Roongtiwaen_US
dc.contributor.mitauthorKim, Min Youngen_US
dc.contributor.mitauthorAdams, Jillianen_US
dc.contributor.mitauthorTrudel, Laura J.en_US
dc.contributor.mitauthorWoo, Leslieen_US
dc.contributor.mitauthorCroy, Robert G.en_US
dc.contributor.mitauthorWogan, Gerald N.en_US
dc.relation.journalEnvironmental and Molecular Mutagenesisen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsWattanawaraporn, Roongtiwa; Kim, Min Young; Adams, Jillian; Trudel, Laura J.; Woo, Leslie L.; Croy, Robert G.; Essigmann, John M.; Wogan, Gerald N.en_US
dc.identifier.orcidhttps://orcid.org/0000-0003-0771-9889
dc.identifier.orcidhttps://orcid.org/0000-0002-2196-5691
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


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