Selective Monoarylation of Acetate Esters and Aryl Methyl Ketones Using Aryl Chlorides
Author(s)Biscoe, Mark R.; Buchwald, Stephen Leffler
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Simple, efficient procedures for the monoarylation of acetate esters and aryl methyl ketones using aryl chlorides are presented. Previously, no general method was available to ensure the highly selective monoarylation of these classes of substrates using aryl chlorides. Using palladium precatalysts recently reported by our group, these reactions are easily accomplished under mild conditions that tolerate a wide array of heterocyclic substrates.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
American Chemical Society (ACS)
Biscoe, Mark R., and Stephen L. Buchwald. “Selective Monoarylation of Acetate Esters and Aryl Methyl Ketones Using Aryl Chlorides.” Organic Letters 11, no. 8 (April 16, 2009): 1773-1775.
Author's final manuscript