Design and Synthesis of a Novel Triptycene-Based Ligand for Modeling Carboxylate-Bridged Diiron Enzyme Active Sites

Author(s)
Li, Yang; Cao, Rui; Lippard, Stephen J.
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Abstract
A novel triptycene-based ligand with a preorganized framework was designed to model carboxylate-bridged diiron active sites in bacterial multicomponent monooxygenase (BMM) hydroxylase enzymes. The synthesis of the bis(benzoxazole)-appended ligand L1 depicted was accomplished in 11 steps. Reaction of L1 with iron(II) triflate and a carboxylate source afforded the desired diiron(II) complex [Fe[subscript 2]L1(μ-OH)(μ-O[subscript 2]CAr[superscript Tol])(OTf)[subscript 2]].
Date issued
2011-08
URI
http://hdl.handle.net/1721.1/82153
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Organic Letters
Publisher
American Chemical Society (ACS)
Citation
Li, Yang, Rui Cao, and Stephen J. Lippard. “Design and Synthesis of a Novel Triptycene-Based Ligand for Modeling Carboxylate-Bridged Diiron Enzyme Active Sites.” Organic Letters 13, no. 19 (October 7, 2011): 5052-5055.
Version: Author's final manuscript
ISSN
1523-7060
1523-7052
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