Directed Heterodimerization: Stereocontrolled Assembly via Solvent-Caged Unsymmetrical Diazene Fragmentation
Author(s)Movassaghi, Mohammad; Ahmad, Omar K.; Lathrop, Stephen
DownloadMovassaghi_Directed heterodimerization.pdf (2.730Mb)
MetadataShow full item record
A general strategy for the directed and stereocontrolled assembly of carbon–carbon linked heterodimeric hexahydropyrroloindoles is described. The stepwise union of complex amines in the form of mixed diazenes followed by photoexpulsion of dinitrogen in a solvent cage provides completely guided assembly at challenging C[3 over sp]–C[3 over sp] and C[3 over sp]–C[2 over sp] connections.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Journal of the American Chemical Society
American Chemical Society (ACS)
Movassaghi, Mohammad, Omar K. Ahmad, and Stephen P. Lathrop. “Directed Heterodimerization: Stereocontrolled Assembly via Solvent-Caged Unsymmetrical Diazene Fragmentation.” Journal of the American Chemical Society 133, no. 33 (August 24, 2011): 13002-13005.
Author's final manuscript