DNA Self-Assembly of Targeted Near-Infrared-Responsive Gold Nanoparticles for Cancer Thermo-Chemotherapy

Author(s)
Xiao, Zeyu; Ji, Changwei; Shi, Jinjun; Frieder, Jillian; Wu, Jun; ... Show more
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Abstract
Targeted cancer therapy: Inspired by the ability of DNA hybridization, a targeted near-infrared (NIR) light-responsive delivery system has been developed through simple DNA self-assembly (see picture; PEG=polyethylene glycol). This DNA-based platform shows the ability of releasing therapeutics upon near-infrared irradiation, and remarkable targeted thermo- and chemotherapeutic efficacy in vitro and in vivo.
Date issued
2012-10
URI
http://hdl.handle.net/1721.1/82885
Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science; MIT-Harvard Center for Cancer Nanotechnology Excellence; Massachusetts Institute of Technology. Department of Chemical Engineering; Koch Institute for Integrative Cancer Research at MIT
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Xiao, Zeyu, Changwei Ji, Jinjun Shi, Eric M. Pridgen, Jillian Frieder, Jun Wu, and Omid C. Farokhzad. “DNA Self-Assembly of Targeted Near-Infrared-Responsive Gold Nanoparticles for Cancer Thermo-Chemotherapy.” Angewandte Chemie International Edition 51, no. 47 (November 19, 2012): 11853-11857. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Version: Final published version
ISSN
14337851
1521-3773
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