DNA Self-Assembly of Targeted Near-Infrared-Responsive Gold Nanoparticles for Cancer Thermo-Chemotherapy
Author(s)Xiao, Zeyu; Ji, Changwei; Shi, Jinjun; Frieder, Jillian; Wu, Jun; Farokhzad, Omid C.; Shi, JinJun; Pridgen, Eric M.; ... Show more Show less
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Targeted cancer therapy: Inspired by the ability of DNA hybridization, a targeted near-infrared (NIR) light-responsive delivery system has been developed through simple DNA self-assembly (see picture; PEG=polyethylene glycol). This DNA-based platform shows the ability of releasing therapeutics upon near-infrared irradiation, and remarkable targeted thermo- and chemotherapeutic efficacy in vitro and in vivo.
DepartmentInstitute for Medical Engineering and Science; MIT-Harvard Center for Cancer Nanotechnology Excellence; Massachusetts Institute of Technology. Department of Chemical Engineering; Koch Institute for Integrative Cancer Research at MIT
Angewandte Chemie International Edition
Xiao, Zeyu, Changwei Ji, Jinjun Shi, Eric M. Pridgen, Jillian Frieder, Jun Wu, and Omid C. Farokhzad. “DNA Self-Assembly of Targeted Near-Infrared-Responsive Gold Nanoparticles for Cancer Thermo-Chemotherapy.” Angewandte Chemie International Edition 51, no. 47 (November 19, 2012): 11853-11857. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Final published version