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DNA Self-Assembly of Targeted Near-Infrared-Responsive Gold Nanoparticles for Cancer Thermo-Chemotherapy

dc.contributor.authorXiao, Zeyu
dc.contributor.authorJi, Changwei
dc.contributor.authorShi, Jinjun
dc.contributor.authorFrieder, Jillian
dc.contributor.authorWu, Jun
dc.contributor.authorFarokhzad, Omid C.
dc.contributor.authorShi, JinJun
dc.contributor.authorPridgen, Eric M.
dc.date.accessioned2013-12-09T15:26:30Z
dc.date.available2013-12-09T15:26:30Z
dc.date.issued2012-10
dc.date.submitted2012-09
dc.identifier.issn14337851
dc.identifier.issn1521-3773
dc.identifier.urihttp://hdl.handle.net/1721.1/82885
dc.description.abstractTargeted cancer therapy: Inspired by the ability of DNA hybridization, a targeted near-infrared (NIR) light-responsive delivery system has been developed through simple DNA self-assembly (see picture; PEG=polyethylene glycol). This DNA-based platform shows the ability of releasing therapeutics upon near-infrared irradiation, and remarkable targeted thermo- and chemotherapeutic efficacy in vitro and in vivo.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant CA151884)en_US
dc.description.sponsorshipProstate Cancer Foundation (Program in Cancer Nanotherapeutics)en_US
dc.language.isoen_US
dc.publisherWiley Blackwellen_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/anie.201204018en_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/en_US
dc.sourcePMCen_US
dc.titleDNA Self-Assembly of Targeted Near-Infrared-Responsive Gold Nanoparticles for Cancer Thermo-Chemotherapyen_US
dc.typeArticleen_US
dc.identifier.citationXiao, Zeyu, Changwei Ji, Jinjun Shi, Eric M. Pridgen, Jillian Frieder, Jun Wu, and Omid C. Farokhzad. “DNA Self-Assembly of Targeted Near-Infrared-Responsive Gold Nanoparticles for Cancer Thermo-Chemotherapy.” Angewandte Chemie International Edition 51, no. 47 (November 19, 2012): 11853-11857. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheimen_US
dc.contributor.departmentMassachusetts Institute of Technology. Institute for Medical Engineering & Scienceen_US
dc.contributor.departmentMIT-Harvard Center for Cancer Nanotechnology Excellenceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.mitauthorShi, JinJunen_US
dc.contributor.mitauthorPridgen, Eric Michaelen_US
dc.contributor.mitauthorWu, Junen_US
dc.contributor.mitauthorFarokhzad, Omid C.en_US
dc.relation.journalAngewandte Chemie International Editionen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsXiao, Zeyu; Ji, Changwei; Shi, Jinjun; Pridgen, Eric M.; Frieder, Jillian; Wu, Jun; Farokhzad, Omid C.en_US
dc.identifier.orcidhttps://orcid.org/0000-0001-6518-0311
dc.identifier.orcidhttps://orcid.org/0000-0002-2640-3006
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


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