Cables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowth
Author(s)Zukerberg, Lawrence R; Patrick, Gentry N; Nikolic, Margareta; Humbert, Sandrine; Wu, Chin-Lee; Vidal, Marc; Van Etten, Richard A; Tsai, Li-Huei; Lanier, Lorene M.; Gertler, Frank; ... Show more Show less
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Cyclin-dependent kinase 5 (Cdk5) is a small serine/threonine kinase that plays a pivotal role during development of the CNS. Cables, a novel protein, interacts with Cdk5 in brain lysates. Cables also binds to and is a substrate of the c-Abl tyrosine kinase. Active c-Abl kinase leads to Cdk5 tyrosine phosphorylation, and this phosphorylation is enhanced by Cables. Phosphorylation of Cdk5 by c-Abl occurs on tyrosine 15 (Y15), which is stimulatory for p35/Cdk5 kinase activity. Expression of antisense Cables in primary cortical neurons inhibited neurite outgrowth. Furthermore, expression of active Abl resulted in lengthening of neurites. The data provide evidence for a Cables-mediated interplay between the Cdk5 and c-Abl signaling pathways in the developing nervous system.
DepartmentMassachusetts Institute of Technology. Department of Biology
Zukerberg, Lawrence R, Gentry N Patrick, Margareta Nikolic, Sandrine Humbert, Chin-Lee Wu, Lorene M Lanier, Frank B Gertler, Marc Vidal, Richard A Van Etten, and Li-Huei Tsai. “Cables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowth.” Neuron 26, no. 3 (June 2000): 633-646. Copyright © 2000 Cell Press
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