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dc.contributor.authorZukerberg, Lawrence R
dc.contributor.authorPatrick, Gentry N
dc.contributor.authorNikolic, Margareta
dc.contributor.authorHumbert, Sandrine
dc.contributor.authorWu, Chin-Lee
dc.contributor.authorVidal, Marc
dc.contributor.authorVan Etten, Richard A
dc.contributor.authorTsai, Li-Huei
dc.contributor.authorLanier, Lorene M.
dc.contributor.authorGertler, Frank
dc.date.accessioned2014-01-06T16:19:19Z
dc.date.available2014-01-06T16:19:19Z
dc.date.issued2000-06
dc.date.submitted2000-04
dc.identifier.issn08966273
dc.identifier.issn1097-4199
dc.identifier.urihttp://hdl.handle.net/1721.1/83489
dc.description.abstractCyclin-dependent kinase 5 (Cdk5) is a small serine/threonine kinase that plays a pivotal role during development of the CNS. Cables, a novel protein, interacts with Cdk5 in brain lysates. Cables also binds to and is a substrate of the c-Abl tyrosine kinase. Active c-Abl kinase leads to Cdk5 tyrosine phosphorylation, and this phosphorylation is enhanced by Cables. Phosphorylation of Cdk5 by c-Abl occurs on tyrosine 15 (Y15), which is stimulatory for p35/Cdk5 kinase activity. Expression of antisense Cables in primary cortical neurons inhibited neurite outgrowth. Furthermore, expression of active Abl resulted in lengthening of neurites. The data provide evidence for a Cables-mediated interplay between the Cdk5 and c-Abl signaling pathways in the developing nervous system.en_US
dc.description.sponsorshipAnna Fuller Funden_US
dc.description.sponsorshipMerck & Co., Inc.en_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/S0896-6273(00)81200-3en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceElsevier Open Archiveen_US
dc.titleCables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowthen_US
dc.typeArticleen_US
dc.identifier.citationZukerberg, Lawrence R, Gentry N Patrick, Margareta Nikolic, Sandrine Humbert, Chin-Lee Wu, Lorene M Lanier, Frank B Gertler, Marc Vidal, Richard A Van Etten, and Li-Huei Tsai. “Cables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowth.” Neuron 26, no. 3 (June 2000): 633-646. Copyright © 2000 Cell Pressen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.mitauthorLanier, Lorene M.en_US
dc.contributor.mitauthorGertler, Franken_US
dc.relation.journalNeuronen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsZukerberg, Lawrence R; Patrick, Gentry N; Nikolic, Margareta; Humbert, Sandrine; Wu, Chin-Lee; Lanier, Lorene M; Gertler, Frank B; Vidal, Marc; Van Etten, Richard A; Tsai, Li-Hueien_US
dc.identifier.orcidhttps://orcid.org/0000-0003-3214-4554
mit.licensePUBLISHER_POLICYen_US


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