dc.contributor.author | Zukerberg, Lawrence R | |
dc.contributor.author | Patrick, Gentry N | |
dc.contributor.author | Nikolic, Margareta | |
dc.contributor.author | Humbert, Sandrine | |
dc.contributor.author | Wu, Chin-Lee | |
dc.contributor.author | Vidal, Marc | |
dc.contributor.author | Van Etten, Richard A | |
dc.contributor.author | Tsai, Li-Huei | |
dc.contributor.author | Lanier, Lorene M. | |
dc.contributor.author | Gertler, Frank | |
dc.date.accessioned | 2014-01-06T16:19:19Z | |
dc.date.available | 2014-01-06T16:19:19Z | |
dc.date.issued | 2000-06 | |
dc.date.submitted | 2000-04 | |
dc.identifier.issn | 08966273 | |
dc.identifier.issn | 1097-4199 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/83489 | |
dc.description.abstract | Cyclin-dependent kinase 5 (Cdk5) is a small serine/threonine kinase that plays a pivotal role during development of the CNS. Cables, a novel protein, interacts with Cdk5 in brain lysates. Cables also binds to and is a substrate of the c-Abl tyrosine kinase. Active c-Abl kinase leads to Cdk5 tyrosine phosphorylation, and this phosphorylation is enhanced by Cables. Phosphorylation of Cdk5 by c-Abl occurs on tyrosine 15 (Y15), which is stimulatory for p35/Cdk5 kinase activity. Expression of antisense Cables in primary cortical neurons inhibited neurite outgrowth. Furthermore, expression of active Abl resulted in lengthening of neurites. The data provide evidence for a Cables-mediated interplay between the Cdk5 and c-Abl signaling pathways in the developing nervous system. | en_US |
dc.description.sponsorship | Anna Fuller Fund | en_US |
dc.description.sponsorship | Merck & Co., Inc. | en_US |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1016/S0896-6273(00)81200-3 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | Elsevier Open Archive | en_US |
dc.title | Cables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowth | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Zukerberg, Lawrence R, Gentry N Patrick, Margareta Nikolic, Sandrine Humbert, Chin-Lee Wu, Lorene M Lanier, Frank B Gertler, Marc Vidal, Richard A Van Etten, and Li-Huei Tsai. “Cables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowth.” Neuron 26, no. 3 (June 2000): 633-646. Copyright © 2000 Cell Press | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
dc.contributor.mitauthor | Lanier, Lorene M. | en_US |
dc.contributor.mitauthor | Gertler, Frank | en_US |
dc.relation.journal | Neuron | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Zukerberg, Lawrence R; Patrick, Gentry N; Nikolic, Margareta; Humbert, Sandrine; Wu, Chin-Lee; Lanier, Lorene M; Gertler, Frank B; Vidal, Marc; Van Etten, Richard A; Tsai, Li-Huei | en_US |
dc.identifier.orcid | https://orcid.org/0000-0003-3214-4554 | |
mit.license | PUBLISHER_POLICY | en_US |
mit.metadata.status | Complete | |