Calorie restriction and sirtuins revisited
Author(s)Guarente, Leonard Pershing
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Calorie or dietary restriction (CR) has attracted attention because it is the oldest and most robust way to extend rodent life span. The idea that the nutrient sensors, termed sirtuins, might mediate effects of CR was proposed 13 years ago and has been challenged in the intervening years. This review addresses these challenges and draws from a great body of new data in the sirtuin field that shows a systematic redirection of mammalian physiology in response to diet by sirtuins. The prospects for drugs that can deliver at least a subset of the benefits of CR seems very real.
DepartmentMassachusetts Institute of Technology. Department of Biology; Paul F. Glenn Center for Biology of Aging Research (Massachusetts Institute of Technology)
Genes & Development
Cold Spring Harbor Laboratory Press
Guarente, L. “Calorie restriction and sirtuins revisited.” Genes & Development 27, no. 19 (October 10, 2013): 2072-2085.
Author's final manuscript