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dc.contributor.authorGuarente, Leonard Pershing
dc.date.accessioned2014-01-24T18:27:51Z
dc.date.available2014-01-24T18:27:51Z
dc.date.issued2013-10
dc.identifier.issn0890-9369
dc.identifier.issn1549-5477
dc.identifier.urihttp://hdl.handle.net/1721.1/84509
dc.description.abstractCalorie or dietary restriction (CR) has attracted attention because it is the oldest and most robust way to extend rodent life span. The idea that the nutrient sensors, termed sirtuins, might mediate effects of CR was proposed 13 years ago and has been challenged in the intervening years. This review addresses these challenges and draws from a great body of new data in the sirtuin field that shows a systematic redirection of mammalian physiology in response to diet by sirtuins. The prospects for drugs that can deliver at least a subset of the benefits of CR seems very real.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.)en_US
dc.description.sponsorshipPaul F. Glenn Foundationen_US
dc.language.isoen_US
dc.publisherCold Spring Harbor Laboratory Pressen_US
dc.relation.isversionofhttp://dx.doi.org/10.1101/gad.227439.113en_US
dc.rightsCreative Commons Attribution-Noncommercial 3.0en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/en_US
dc.sourceCold Spring Harbor Laboratory Pressen_US
dc.titleCalorie restriction and sirtuins revisiteden_US
dc.typeArticleen_US
dc.identifier.citationGuarente, L. “Calorie restriction and sirtuins revisited.” Genes & Development 27, no. 19 (October 10, 2013): 2072-2085.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Glenn Laboratory for the Science of Agingen_US
dc.contributor.mitauthorGuarente, Leonard Pershingen_US
dc.relation.journalGenes & Developmenten_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsGuarente, L.en_US
dc.identifier.orcidhttps://orcid.org/0000-0003-4064-2510
mit.licensePUBLISHER_CCen_US


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