Peptide Fragment Coupling Using a Continuous-Flow Photochemical Rearrangement of Nitrones
Author(s)Zhang, Yuan; Blackman, Melissa L.; Leduc, Andrew B.; Jamison, Timothy F.
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A general approach for amide bond formation by way of a continuous-flow photochemical rearrangement of nitrones was described (see scheme). Simple aryl-alkyl amide bonds as well as complex peptide bonds were constructed efficiently with a residence time less than 20 minutes. A tetrapeptide was synthesized in this way and the method could be applied to peptide fragment coupling.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Angewandte Chemie International Edition
Zhang, Yuan, Melissa L. Blackman, Andrew B. Leduc, and Timothy F. Jamison. “Peptide Fragment Coupling Using a Continuous-Flow Photochemical Rearrangement of Nitrones.” Angewandte Chemie International Edition 52, no. 15 (April 8, 2013): 4251-4255.
Author's final manuscript