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Peptide Fragment Coupling Using a Continuous-Flow Photochemical Rearrangement of Nitrones

dc.contributor.authorZhang, Yuan
dc.contributor.authorBlackman, Melissa L.
dc.contributor.authorLeduc, Andrew B.
dc.contributor.authorJamison, Timothy F.
dc.date.accessioned2014-01-27T19:41:12Z
dc.date.available2014-01-27T19:41:12Z
dc.date.issued2013-03
dc.date.submitted2013-01
dc.identifier.issn14337851
dc.identifier.issn1521-3773
dc.identifier.urihttp://hdl.handle.net/1721.1/84600
dc.description.abstractA general approach for amide bond formation by way of a continuous-flow photochemical rearrangement of nitrones was described (see scheme). Simple aryl-alkyl amide bonds as well as complex peptide bonds were constructed efficiently with a residence time less than 20 minutes. A tetrapeptide was synthesized in this way and the method could be applied to peptide fragment coupling.en_US
dc.description.sponsorshipNovartis-MIT Center for Continuous Manufacturingen_US
dc.language.isoen_US
dc.publisherWiley Blackwellen_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/anie.201300504en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alike 3.0en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.sourceProf. Jamison via Erja Kajosaloen_US
dc.titlePeptide Fragment Coupling Using a Continuous-Flow Photochemical Rearrangement of Nitronesen_US
dc.typeArticleen_US
dc.identifier.citationZhang, Yuan, Melissa L. Blackman, Andrew B. Leduc, and Timothy F. Jamison. “Peptide Fragment Coupling Using a Continuous-Flow Photochemical Rearrangement of Nitrones.” Angewandte Chemie International Edition 52, no. 15 (April 8, 2013): 4251-4255.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.approverJamison, Timothy F.en_US
dc.contributor.mitauthorZhang, Yuanen_US
dc.contributor.mitauthorBlackman, Melissa L.en_US
dc.contributor.mitauthorLeduc, Andrew B.en_US
dc.contributor.mitauthorJamison, Timothy F.en_US
dc.relation.journalAngewandte Chemie International Editionen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsZhang, Yuan; Blackman, Melissa L.; Leduc, Andrew B.; Jamison, Timothy F.en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-8601-7799
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


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