From stem cell to erythroblast: Regulation of red cell production at multiple levels by multiple hormones
Author(s)Lodish, Harvey F.; Flygare, Johan; Chou, Song
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This article reviews the regulation of production of red blood cells at several levels: (1) the ability of erythropoietin and adhesion to a fibronectin matrix to stimulate the rapid production of red cells by inducing terminal proliferation and differentiation of committed erythroid CFU-E progenitors; (2) the regulated expansion of the pool of earlier BFU-E erythroid progenitors by glucocorticoids and other factors that occurs during chronic anemia or inflammation; and (3) the expansion of thehematopoietic cell pool to produce more progenitors of all hematopoietic lineages.
DepartmentMassachusetts Institute of Technology. Department of Biology
John Wiley & Sons, Inc
Lodish, Harvey, Johan Flygare, and Song Chou. “From stem cell to erythroblast: Regulation of red cell production at multiple levels by multiple hormones.” IUBMB Life 62, no. 7 (July 19, 2010): 492-496.
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