Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles
Author(s)Youngsaye, Willmen; Dockendorff, Chris; Hartland, Cathy L.; Bittker, Joshua A.; Dandapani, Sivaraman; Palmer, Michelle; Whitesell, Luke; Lindquist, Susan; Schreiber, Stuart L.; Munoz, Benito; ... Show more Show less
MetadataShow full item record
Continuing efforts to discover novel means of combating fluconazole resistance in Candida albicans have identified an indole derivative that sensitizes strains demonstrating resistance to fluconazole. This tetracycle (3, ML229) does not appear to act through established Hsp90 or calcineurin pathways to chemosensitize C. albicans, as determined in Saccharomyces cerevisiae models, and may be a useful probe to uncover alternative resistance pathways.
DepartmentMassachusetts Institute of Technology. Department of Biology; Whitehead Institute for Biomedical Research
Bioorganic & Medicinal Chemistry Letters
Youngsaye, Willmen, Chris Dockendorff, Benjamin Vincent, Cathy L. Hartland, Joshua A. Bittker, Sivaraman Dandapani, Michelle Palmer, et al. “Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles.” Bioorganic & Medicinal Chemistry Letters 22, no. 9 (May 2012): 3362-3365.
Author's final manuscript