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Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles

dc.contributor.authorYoungsaye, Willmen
dc.contributor.authorDockendorff, Chris
dc.contributor.authorHartland, Cathy L.
dc.contributor.authorBittker, Joshua A.
dc.contributor.authorDandapani, Sivaraman
dc.contributor.authorPalmer, Michelle
dc.contributor.authorWhitesell, Luke
dc.contributor.authorLindquist, Susan
dc.contributor.authorSchreiber, Stuart L.
dc.contributor.authorMunoz, Benito
dc.date.accessioned2014-02-14T17:14:28Z
dc.date.available2014-02-14T17:14:28Z
dc.date.issued2012-05
dc.identifier.issn0960894X
dc.identifier.urihttp://hdl.handle.net/1721.1/84955
dc.description.abstractContinuing efforts to discover novel means of combating fluconazole resistance in Candida albicans have identified an indole derivative that sensitizes strains demonstrating resistance to fluconazole. This tetracycle (3, ML229) does not appear to act through established Hsp90 or calcineurin pathways to chemosensitize C. albicans, as determined in Saccharomyces cerevisiae models, and may be a useful probe to uncover alternative resistance pathways.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NIH-MLPCN program (1 U54 HG005032-1))en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NIH (1 R03 MH086456-01))en_US
dc.language.isoen_US
dc.publisherElsevier B.V.en_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.bmcl.2012.02.035en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleOvercoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indolesen_US
dc.typeArticleen_US
dc.identifier.citationYoungsaye, Willmen, Chris Dockendorff, Benjamin Vincent, Cathy L. Hartland, Joshua A. Bittker, Sivaraman Dandapani, Michelle Palmer, et al. “Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles.” Bioorganic & Medicinal Chemistry Letters 22, no. 9 (May 2012): 3362-3365.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentWhitehead Institute for Biomedical Researchen_US
dc.contributor.mitauthorLindquist, Susanen_US
dc.contributor.mitauthorWhitesell, Lukeen_US
dc.relation.journalBioorganic & Medicinal Chemistry Lettersen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsYoungsaye, Willmen; Dockendorff, Chris; Vincent, Benjamin; Hartland, Cathy L.; Bittker, Joshua A.; Dandapani, Sivaraman; Palmer, Michelle; Whitesell, Luke; Lindquist, Susan; Schreiber, Stuart L.; Munoz, Benitoen_US
dc.identifier.orcidhttps://orcid.org/0000-0003-1307-882X
mit.licenseOPEN_ACCESS_POLICYen_US


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