Cascade Palladium Catalysis: A Predictable and Selectable Regiocontrolled Synthesis of N-Arylbenzimidazoles
Author(s)Jui, Nathan T.; Buchwald, Stephen Leffler
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By choice: The palladium-catalyzed cascade reaction of 2-chloroaryl sulfonates with arylamine and amide nucleophiles provides direct access to N-arylbenzimidazoles. This strategy selectively produces the heterocycles based on chemoselective oxidative addition. 2-Chloroaryl triflates (Tf) produce one regioisomer and the corresponding 2-chloroaryl mesylates (Ms) deliver the other in a selectable manner.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Angewandte Chemie International Edition
John Wiley & Sons, Inc
Jui, Nathan T., and Stephen L. Buchwald. “Cascade Palladium Catalysis: A Predictable and Selectable Regiocontrolled Synthesis of N-Arylbenzimidazole.” Angewandte Chemie International Edition 52, no. 44 (October 25, 2013): 11624-11627.
Author's final manuscript