The structural basis for specific decoding of AUA by isoleucine tRNA on the ribosome
Author(s)Voorhees, Rebecca M; Mandal, Debabrata; Neubauer, Cajetan; Koehrer, Caroline; Rajbhandary, Uttam L.; Ramakrishnan, V.; ... Show more Show less
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Decoding of the AUA isoleucine codon in bacteria and archaea requires modification of a C in the anticodon wobble position of the isoleucine tRNA. Here, we report the crystal structure of the archaeal tRNA2Ile, which contains the modification agmatidine in its anticodon, in complex with the AUA codon on the 70S ribosome. The structure illustrates how agmatidine confers codon specificity for AUA over AUG.
DepartmentMassachusetts Institute of Technology. Department of Biology
Nature Structural & Molecular Biology
Nature Publishing Group
Voorhees, Rebecca M, Debabrata Mandal, Cajetan Neubauer, Caroline Köhrer, Uttam L RajBhandary, and V Ramakrishnan. “The structural basis for specific decoding of AUA by isoleucine tRNA on the ribosome.” Nature Structural & Molecular Biology 20, no. 5 (March 31, 2013): 641-643.
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