The structural basis for specific decoding of AUA by isoleucine tRNA on the ribosome

Author(s)
Voorhees, Rebecca M; Mandal, Debabrata; Neubauer, Cajetan; Koehrer, Caroline; Ramakrishnan, V.; ... Show more
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Abstract
Decoding of the AUA isoleucine codon in bacteria and archaea requires modification of a C in the anticodon wobble position of the isoleucine tRNA. Here, we report the crystal structure of the archaeal tRNA2Ile, which contains the modification agmatidine in its anticodon, in complex with the AUA codon on the 70S ribosome. The structure illustrates how agmatidine confers codon specificity for AUA over AUG.
Date issued
2013-03
URI
http://hdl.handle.net/1721.1/85096
Department
Massachusetts Institute of Technology. Department of Biology
Journal
Nature Structural & Molecular Biology
Publisher
Nature Publishing Group
Citation
Voorhees, Rebecca M, Debabrata Mandal, Cajetan Neubauer, Caroline Köhrer, Uttam L RajBhandary, and V Ramakrishnan. “The structural basis for specific decoding of AUA by isoleucine tRNA on the ribosome.” Nature Structural & Molecular Biology 20, no. 5 (March 31, 2013): 641-643.
Version: Author's final manuscript
ISSN
1545-9993
1545-9985
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