| dc.contributor.author | Voorhees, Rebecca M | |
| dc.contributor.author | Mandal, Debabrata | |
| dc.contributor.author | Neubauer, Cajetan | |
| dc.contributor.author | Koehrer, Caroline | |
| dc.contributor.author | Ramakrishnan, V. | |
| dc.contributor.author | Rajbhandary, Uttam L | |
| dc.date.accessioned | 2014-02-26T17:41:43Z | |
| dc.date.available | 2014-02-26T17:41:43Z | |
| dc.date.issued | 2013-03 | |
| dc.identifier.issn | 1545-9993 | |
| dc.identifier.issn | 1545-9985 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/85096 | |
| dc.description.abstract | Decoding of the AUA isoleucine codon in bacteria and archaea requires modification of a C in the anticodon wobble position of the isoleucine tRNA. Here, we report the crystal structure of the archaeal tRNA2Ile, which contains the modification agmatidine in its anticodon, in complex with the AUA codon on the 70S ribosome. The structure illustrates how agmatidine confers codon specificity for AUA over AUG. | en_US |
| dc.description.sponsorship | Medical Research Council (Great Britain) (grant U105184332) | en_US |
| dc.description.sponsorship | Agouron Institute | en_US |
| dc.description.sponsorship | Wellcome Trust (London, England) | en_US |
| dc.description.sponsorship | Louis-Jeantet Foundation | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (grant GM17151) | en_US |
| dc.description.sponsorship | University of Cambridge (Gates Cambridge Scholarship) | en_US |
| dc.description.sponsorship | Peterhouse (University of Cambridge) | en_US |
| dc.description.sponsorship | Boehringer Ingelheim Fonds | en_US |
| dc.language.iso | en_US | |
| dc.publisher | Nature Publishing Group | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1038/nsmb.2545 | en_US |
| dc.rights | Creative Commons Attribution-Noncommercial-Share Alike | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | en_US |
| dc.source | PMC | en_US |
| dc.title | The structural basis for specific decoding of AUA by isoleucine tRNA on the ribosome | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Voorhees, Rebecca M, Debabrata Mandal, Cajetan Neubauer, Caroline Köhrer, Uttam L RajBhandary, and V Ramakrishnan. “The structural basis for specific decoding of AUA by isoleucine tRNA on the ribosome.” Nature Structural & Molecular Biology 20, no. 5 (March 31, 2013): 641-643. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
| dc.contributor.mitauthor | Mandal, Debabrata | en_US |
| dc.contributor.mitauthor | Koehrer, Caroline | en_US |
| dc.contributor.mitauthor | Rajbhandary, Uttam L. | en_US |
| dc.relation.journal | Nature Structural & Molecular Biology | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Voorhees, Rebecca M; Mandal, Debabrata; Neubauer, Cajetan; Köhrer, Caroline; RajBhandary, Uttam L; Ramakrishnan, V | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0002-4530-5647 | |
| mit.license | OPEN_ACCESS_POLICY | en_US |
| mit.metadata.status | Complete | |
