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Bacteria and the Aging and Longevity of Caenorhabditis elegans

Author(s)
Kim, Dennis H.
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Abstract
The molecular genetic analysis of longevity of Caenorhabditis elegans has yielded fundamental insights into evolutionarily conserved pathways and processes governing the physiology of aging. Recent studies suggest that interactions between C. elegans and its microbial environment may influence the aging and longevity of this simple host organism. Experimental evidence supports a role for bacteria in affecting longevity through distinct mechanisms—as a nutrient source, as a potential pathogen that induces double-edged innate immune and stress responses, and as a coevolved sensory stimulus that modulates neuronal signaling pathways regulating longevity. Motivating this review is the anticipation that the molecular genetic dissection of the integrated host immune, stress, and neuroendocrine responses to microbes in C. elegans will uncover basic insights into the cellular and organismal physiology that governs aging and longevity.
Date issued
2013-11
URI
http://hdl.handle.net/1721.1/85594
Department
Massachusetts Institute of Technology. Department of Biology
Journal
Annual Review of Genetics
Publisher
Annual Reviews
Citation
Kim, Dennis H. “ Bacteria and the Aging and Longevity of Caenorhabditis Elegans .” Annu. Rev. Genet. 47, no. 1 (November 23, 2013): 233–246.
Version: Author's final manuscript
ISSN
0066-4197
1545-2948

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