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dc.contributor.authorKim, Dennis H.
dc.date.accessioned2014-03-10T19:39:09Z
dc.date.available2014-03-10T19:39:09Z
dc.date.issued2013-11
dc.identifier.issn0066-4197
dc.identifier.issn1545-2948
dc.identifier.urihttp://hdl.handle.net/1721.1/85594
dc.description.abstractThe molecular genetic analysis of longevity of Caenorhabditis elegans has yielded fundamental insights into evolutionarily conserved pathways and processes governing the physiology of aging. Recent studies suggest that interactions between C. elegans and its microbial environment may influence the aging and longevity of this simple host organism. Experimental evidence supports a role for bacteria in affecting longevity through distinct mechanisms—as a nutrient source, as a potential pathogen that induces double-edged innate immune and stress responses, and as a coevolved sensory stimulus that modulates neuronal signaling pathways regulating longevity. Motivating this review is the anticipation that the molecular genetic dissection of the integrated host immune, stress, and neuroendocrine responses to microbes in C. elegans will uncover basic insights into the cellular and organismal physiology that governs aging and longevity.en_US
dc.description.sponsorshipNational Institute of General Medical Sciences (U.S.)en_US
dc.description.sponsorshipEllison Medical Foundationen_US
dc.language.isoen_US
dc.publisherAnnual Reviewsen_US
dc.relation.isversionofhttp://dx.doi.org/10.1146/annurev-genet-111212-133352en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourceKimen_US
dc.titleBacteria and the Aging and Longevity of Caenorhabditis elegansen_US
dc.typeArticleen_US
dc.identifier.citationKim, Dennis H. “ Bacteria and the Aging and Longevity of Caenorhabditis Elegans .” Annu. Rev. Genet. 47, no. 1 (November 23, 2013): 233–246.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.approverKim, Dennis H.en_US
dc.contributor.mitauthorKim, Dennis H.en_US
dc.relation.journalAnnual Review of Geneticsen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsKim, Dennis H.en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-4109-5152
mit.licenseOPEN_ACCESS_POLICYen_US


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