| dc.contributor.author | Schwartz, Robert E. | |
| dc.contributor.author | Trehan, Kartik | |
| dc.contributor.author | Andrus, Linda | |
| dc.contributor.author | Sheahan, Timothy P. | |
| dc.contributor.author | Ploss, Alexander | |
| dc.contributor.author | Duncan, Stephen A. | |
| dc.contributor.author | Rice, Charles M. | |
| dc.contributor.author | Bhatia, Sangeeta N | |
| dc.date.accessioned | 2014-03-28T19:21:08Z | |
| dc.date.available | 2014-03-28T19:21:08Z | |
| dc.date.issued | 2012-01 | |
| dc.date.submitted | 2011-10 | |
| dc.identifier.issn | 0027-8424 | |
| dc.identifier.issn | 1091-6490 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/85972 | |
| dc.description.abstract | Human pathogens impact patient health through a complex interplay with the host, but models to study the role of host genetics in this process are limited. Human induced pluripotent stem cells (iPSCs) offer the ability to produce host-specific differentiated cells and thus have the potential to transform the study of infectious disease; however, no iPSC models of infectious disease have been described. Here we report that hepatocyte-like cells derived from iPSCs support the entire life cycle of hepatitis C virus, including inflammatory responses to infection, enabling studies of how host genetics impact viral pathogenesis. | en_US |
| dc.description.sponsorship | National Institute of Allergy and Infectious Diseases (U.S.) (Grant R01 AIO72613) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (NIH Roadmap for Medical Research Grant 1 R01 DK085713-01) | en_US |
| dc.description.sponsorship | Greenberg Institute for Medical Research | en_US |
| dc.description.sponsorship | Starr Foundation | en_US |
| dc.description.sponsorship | Howard Hughes Medical Institute | en_US |
| dc.language.iso | en_US | |
| dc.publisher | National Academy of Sciences (U.S.) | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1073/pnas.1121400109 | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | PNAS | en_US |
| dc.title | Modeling hepatitis C virus infection using human induced pluripotent stem cells | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Schwartz, R. E., K. Trehan, L. Andrus, T. P. Sheahan, A. Ploss, S. A. Duncan, C. M. Rice, and S. N. Bhatia. “Modeling Hepatitis C Virus Infection Using Human Induced Pluripotent Stem Cells.” Proceedings of the National Academy of Sciences 109, no. 7 (February 14, 2012): 2544–2548. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Institute for Medical Engineering & Science | en_US |
| dc.contributor.department | Harvard University--MIT Division of Health Sciences and Technology | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science | en_US |
| dc.contributor.mitauthor | Schwartz, Robert E. | en_US |
| dc.contributor.mitauthor | Trehan, Kartik | en_US |
| dc.contributor.mitauthor | Bhatia, Sangeeta N. | en_US |
| dc.relation.journal | Proceedings of the National Academy of Sciences | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Schwartz, R. E.; Trehan, K.; Andrus, L.; Sheahan, T. P.; Ploss, A.; Duncan, S. A.; Rice, C. M.; Bhatia, S. N. | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0002-1293-2097 | |
| mit.license | PUBLISHER_POLICY | en_US |
| mit.metadata.status | Complete | |
