Movement-generated afference paired with transcranial magnetic stimulation: an associative stimulation paradigm
Author(s)
Edwards, Dylan J.; Dipietro, Laura; Demirtas-Tatlidede, Asli; Medeiros, Ana H.; Thickbroom, Gary W.; Mastaglia, Francis L.; Pascual-Leone, Alvaro; Krebs, Hermano Igo; ... Show more Show less
Download1743-0003-11-31.pdf (765.0Kb)
PUBLISHER_CC
Publisher with Creative Commons License
Creative Commons Attribution
Terms of use
Metadata
Show full item recordAbstract
Background:
A peripheral nerve stimulus can enhance or suppress the evoked response to transcranial magnetic stimulation (TMS) depending on the latency of the preceding peripheral nerve stimulation (PNS) pulse. Similarly, somatosensory afference from the passively moving limb can transiently alter corticomotor excitability, in a phase-dependent manner. The repeated association of PNS with TMS is known to modulate corticomotor excitability; however, it is unknown whether repeated passive-movement associative stimulation (MAS) has similar effects.
Methods:
In a proof-of-principle study, using a cross-over design, seven healthy subjects received in separate sessions: (1) TMS (120% of the resting motor threshold-RMT, optimal site for Flexor Carpi Radialis) with muscle at rest; (2) TMS paired with cyclic passive movement during extension cyclic passive movement (400 pairs, 1 Hz), with the intervention order randomly assigned. Normality was tested using the Kolmogorov-Smirnov test, then compared to pre-intervention baseline using repeated measures ANOVA with a Dunnet multiple comparisons test.
Results:
MAS led to a progressive and significant decrease in the motor evoked potential (MEP) amplitude over the intervention (R[superscript 2] = 0.6665, P < 0.0001), which was not evident with TMS alone (R[superscript 2] = 0.0068, P = 0.641). Post-intervention excitability reduction, only present with MAS intervention, remained for 20min (0-10min 68.2 ± 4.9%, P < 0.05; 10-20min = 73.3 ± 9.7%, P < 0.05).
Conclusion:
The association of somatosensory afference from the moving limb with TMS over primary motor cortex in healthy subjects can be used to modulate corticomotor excitability, and may have therapeutic implications.
Date issued
2014-03Department
Massachusetts Institute of Technology. Department of Mechanical EngineeringJournal
Journal of NeuroEngineering and Rehabilitation
Publisher
BioMed Central Ltd
Citation
Edwards, Dylan J, Laura Dipietro, Asli Demirtas-Tatlidede, Ana H Medeiros, Gary W Thickbroom, Francis L Mastaglia, Hermano I Krebs, and Alvaro Pascual-Leone. “Movement-Generated Afference Paired with Transcranial Magnetic Stimulation: An Associative Stimulation Paradigm.” J NeuroEngineering Rehabil 11, no. 1 (2014): 31.
Version: Final published version
ISSN
1743-0003