Understanding the TXA seizure connection
Author(s)Schwinn, Debra A.; Mackensen, G. Burkhard; Brown, Emery N.
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Transexamic acid (TXA) is an antifibrinolytic that has been used successfully to prevent blood loss during major surgery. However, as its usage has increased, there have been growing reports of postsurgical seizure events in cardiac surgery patients. In this issue of the JCI, Lecker et al. explore this connection and suggest that TXA-mediated inhibition of glycine receptors may underlie the effect. This finding prompted the authors to explore the preclinical efficacy of common anesthetics that function by reducing the TXA-mediated inhibition to prevent or modify postsurgical seizures.
DepartmentHarvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Journal of Clinical Investigation
American Society for Clinical Investigation
Schwinn, Debra A., G. Burkhard Mackensen, and Emery N. Brown. “Understanding the TXA Seizure Connection.” J. Clin. Invest. 122, no. 12 (December 3, 2012): 4339–4341. © 2012 American Society for Clinical Investigation
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