| dc.contributor.author | Schwinn, Debra A. | |
| dc.contributor.author | Mackensen, G. Burkhard | |
| dc.contributor.author | Brown, Emery N. | |
| dc.date.accessioned | 2014-05-01T17:29:56Z | |
| dc.date.available | 2014-05-01T17:29:56Z | |
| dc.date.issued | 2012-11 | |
| dc.identifier.issn | 0021-9738 | |
| dc.identifier.issn | 1558-8238 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/86337 | |
| dc.description.abstract | Transexamic acid (TXA) is an antifibrinolytic that has been used successfully to prevent blood loss during major surgery. However, as its usage has increased, there have been growing reports of postsurgical seizure events in cardiac surgery patients. In this issue of the JCI, Lecker et al. explore this connection and suggest that TXA-mediated inhibition of glycine receptors may underlie the effect. This finding prompted the authors to explore the preclinical efficacy of common anesthetics that function by reducing the TXA-mediated inhibition to prevent or modify postsurgical seizures. | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Grant DP1OD003646) | en_US |
| dc.language.iso | en_US | |
| dc.publisher | American Society for Clinical Investigation | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1172/jci66724 | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | PMC | en_US |
| dc.title | Understanding the TXA seizure connection | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Schwinn, Debra A., G. Burkhard Mackensen, and Emery N. Brown. “Understanding the TXA Seizure Connection.” J. Clin. Invest. 122, no. 12 (December 3, 2012): 4339–4341. © 2012 American Society for Clinical Investigation | en_US |
| dc.contributor.department | Harvard University--MIT Division of Health Sciences and Technology | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences | en_US |
| dc.contributor.mitauthor | Brown, Emery N. | en_US |
| dc.relation.journal | Journal of Clinical Investigation | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Schwinn, Debra A.; Mackensen, G. Burkhard; Brown, Emery N. | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0003-2668-7819 | |
| mit.license | PUBLISHER_POLICY | en_US |
| mit.metadata.status | Complete | |
