MIT Libraries homeMIT Libraries logoDSpace@MIT

MIT
View Item 
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Spiral microchannel with rectangular and trapezoidal cross-sections for size based particle separation

Author(s)
Guan, Guofeng; Wu, Lidan; Bhagat, Ali Asgar S.; Li, Zirui; Chen, Peter C. Y.; Chao, Shuzhe; Ong, Chong Jin; Han, Jongyoon; ... Show more Show less
Thumbnail
DownloadHan_Spiral microchannel.pdf (1.674Mb)
PUBLISHER_CC

Publisher with Creative Commons License

Creative Commons Attribution

Terms of use
Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License http://creativecommons.org/licenses/by-nc-nd/3.0
Metadata
Show full item record
Abstract
The paper reports a new method for three-dimensional observation of the location of focused particle streams along both the depth and width of the channel cross-section in spiral inertial microfluidic systems. The results confirm that particles are focused near the top and bottom walls of the microchannel cross-section, revealing clear insights on the focusing and separation mechanism. Based on this detailed understanding of the force balance, we introduce a novel spiral microchannel with a trapezoidal cross-section that generates stronger Dean vortices at the outer half of the channel. Experiments show that particles focusing in such device are sensitive to particle size and flow rate, and exhibits a sharp transition from the inner half to the outer half equilibrium positions at a size-dependent critical flow rate. As particle equilibration positions are well segregated based on different focusing mechanisms, a higher separation resolution is achieved over conventional spiral microchannels with rectangular cross-section.
Date issued
2013-03
URI
http://hdl.handle.net/1721.1/86366
Department
Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Journal
Scientific Reports
Publisher
Nature Publishing Group
Citation
Guan, Guofeng, Lidan Wu, Ali Asgar Bhagat, Zirui Li, Peter C. Y. Chen, Shuzhe Chao, Chong Jin Ong, and Jongyoon Han. “Spiral Microchannel with Rectangular and Trapezoidal Cross-Sections for Size Based Particle Separation.” Sci. Rep. 3 (March 18, 2013).
Version: Final published version
ISSN
2045-2322

Collections
  • MIT Open Access Articles

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

Login

Statistics

OA StatisticsStatistics by CountryStatistics by Department
MIT Libraries homeMIT Libraries logo

Find us on

Twitter Instagram YouTube

MIT Libraries navigation

SearchHours & locationsBorrow & requestResearch supportAbout us
PrivacyPermissionsAccessibility
MIT
Massachusetts Institute of Technology
Content created by the MIT Libraries, CC BY-NC unless otherwise noted. Notify us about copyright concerns.