Spiral microchannel with rectangular and trapezoidal cross-sections for size based particle separation
Author(s)Guan, Guofeng; Wu, Lidan; Bhagat, Ali Asgar S.; Li, Zirui; Chen, Peter C. Y.; Chao, Shuzhe; Ong, Chong Jin; Han, Jongyoon; ... Show more Show less
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The paper reports a new method for three-dimensional observation of the location of focused particle streams along both the depth and width of the channel cross-section in spiral inertial microfluidic systems. The results confirm that particles are focused near the top and bottom walls of the microchannel cross-section, revealing clear insights on the focusing and separation mechanism. Based on this detailed understanding of the force balance, we introduce a novel spiral microchannel with a trapezoidal cross-section that generates stronger Dean vortices at the outer half of the channel. Experiments show that particles focusing in such device are sensitive to particle size and flow rate, and exhibits a sharp transition from the inner half to the outer half equilibrium positions at a size-dependent critical flow rate. As particle equilibration positions are well segregated based on different focusing mechanisms, a higher separation resolution is achieved over conventional spiral microchannels with rectangular cross-section.
DepartmentMassachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Nature Publishing Group
Guan, Guofeng, Lidan Wu, Ali Asgar Bhagat, Zirui Li, Peter C. Y. Chen, Shuzhe Chao, Chong Jin Ong, and Jongyoon Han. “Spiral Microchannel with Rectangular and Trapezoidal Cross-Sections for Size Based Particle Separation.” Sci. Rep. 3 (March 18, 2013).
Final published version