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dc.contributor.authorGuan, Guofeng
dc.contributor.authorWu, Lidan
dc.contributor.authorBhagat, Ali Asgar S.
dc.contributor.authorLi, Zirui
dc.contributor.authorChen, Peter C. Y.
dc.contributor.authorChao, Shuzhe
dc.contributor.authorOng, Chong Jin
dc.contributor.authorHan, Jongyoon
dc.date.accessioned2014-05-02T15:19:12Z
dc.date.available2014-05-02T15:19:12Z
dc.date.issued2013-03
dc.date.submitted2012-10
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/1721.1/86366
dc.description.abstractThe paper reports a new method for three-dimensional observation of the location of focused particle streams along both the depth and width of the channel cross-section in spiral inertial microfluidic systems. The results confirm that particles are focused near the top and bottom walls of the microchannel cross-section, revealing clear insights on the focusing and separation mechanism. Based on this detailed understanding of the force balance, we introduce a novel spiral microchannel with a trapezoidal cross-section that generates stronger Dean vortices at the outer half of the channel. Experiments show that particles focusing in such device are sensitive to particle size and flow rate, and exhibits a sharp transition from the inner half to the outer half equilibrium positions at a size-dependent critical flow rate. As particle equilibration positions are well segregated based on different focusing mechanisms, a higher separation resolution is achieved over conventional spiral microchannels with rectangular cross-section.en_US
dc.description.sponsorshipUnited States. Defense Advanced Research Projects Agency. Dialysis-Like Therapeutics (SSC Pacific Grant N66001-11-1-4182)en_US
dc.language.isoen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/srep01475en_US
dc.rightsCreative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0en_US
dc.sourceScientific Reportsen_US
dc.titleSpiral microchannel with rectangular and trapezoidal cross-sections for size based particle separationen_US
dc.typeArticleen_US
dc.identifier.citationGuan, Guofeng, Lidan Wu, Ali Asgar Bhagat, Zirui Li, Peter C. Y. Chen, Shuzhe Chao, Chong Jin Ong, and Jongyoon Han. “Spiral Microchannel with Rectangular and Trapezoidal Cross-Sections for Size Based Particle Separation.” Sci. Rep. 3 (March 18, 2013).en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Scienceen_US
dc.contributor.mitauthorWu, Lidanen_US
dc.contributor.mitauthorHan, Jongyoonen_US
dc.relation.journalScientific Reportsen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsGuan, Guofeng; Wu, Lidan; Bhagat, Ali Asgar; Li, Zirui; Chen, Peter C. Y.; Chao, Shuzhe; Ong, Chong Jin; Han, Jongyoonen_US
dc.identifier.orcidhttps://orcid.org/0000-0001-7215-1439
dc.identifier.orcidhttps://orcid.org/0000-0003-3150-6170
mit.licensePUBLISHER_CCen_US


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