Twofold C−H Functionalization: Palladium-Catalyzed Ortho Arylation of Anilides
Author(s)Brasche, Gordon; Garcia-Fortanet, Jorge; Buchwald, Stephen Leffler
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The ortho arylation of anilides to form biphenyls via a twofold C−H functionalization/C−C bond-forming process is described. The oxidative coupling takes place in the presence of 5−10 mol % of Pd(OAc)[subscript 2], 10−20 mol % of DMSO, and 4−11 equiv of the aryl substrate in TFA under an oxygen atmosphere. No metal-containing cocatalyst is required.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
American Chemical Society
Brasche, Gordon, Jorge Garcia-Fortanet, and Stephen L. Buchwald. “ Twofold C−H Functionalization: Palladium-Catalyzed Ortho Arylation of Anilides.” Org. Lett. 10, no. 11 (June 2008): 2207–2210. © 2008 American Chemical Society.
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