Population Genomics of Early Events in the Ecological Differentiation of Bacteria
Author(s)Shapiro, B. J.; Friedman, J.; Cordero Sanchez, Otto Xavier; Preheim, Sarah Pacocha; Timberlake, Sonia Crago; Szabo, Gitta; Polz, Martin F.; Alm, Eric J.; ... Show more Show less
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Genetic exchange is common among bacteria, but its effect on population diversity during ecological differentiation remains controversial. A fundamental question is whether advantageous mutations lead to selection of clonal genomes or, as in sexual eukaryotes, sweep through populations on their own. Here, we show that in two recently diverged populations of ocean bacteria, ecological differentiation has occurred akin to a sexual mechanism: A few genome regions have swept through subpopulations in a habitat-specific manner, accompanied by gradual separation of gene pools as evidenced by increased habitat specificity of the most recent recombinations. These findings reconcile previous, seemingly contradictory empirical observations of the genetic structure of bacterial populations and point to a more unified process of differentiation in bacteria and sexual eukaryotes than previously thought.
DepartmentMassachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Civil and Environmental Engineering
American Association for the Advancement of Science (AAAS)
Shapiro, B. J., et al. "Population Genomics of Early Events in the Ecological Differentiation of Bacteria." Science 6 April 2012: Vol. 336 no. 6077 pp. 48-51.
Author's final manuscript