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dc.contributor.authorShapiro, B. J.
dc.contributor.authorFriedman, J.
dc.contributor.authorCordero Sanchez, Otto Xavier
dc.contributor.authorPreheim, Sarah Pacocha
dc.contributor.authorTimberlake, Sonia Crago
dc.contributor.authorSzabo, Gitta
dc.contributor.authorPolz, Martin F.
dc.contributor.authorAlm, Eric J.
dc.date.accessioned2014-08-13T13:36:32Z
dc.date.available2014-08-13T13:36:32Z
dc.date.issued2012-04
dc.date.submitted2011-12
dc.identifier.issn0036-8075
dc.identifier.issn1095-9203
dc.identifier.urihttp://hdl.handle.net/1721.1/88692
dc.description.abstractGenetic exchange is common among bacteria, but its effect on population diversity during ecological differentiation remains controversial. A fundamental question is whether advantageous mutations lead to selection of clonal genomes or, as in sexual eukaryotes, sweep through populations on their own. Here, we show that in two recently diverged populations of ocean bacteria, ecological differentiation has occurred akin to a sexual mechanism: A few genome regions have swept through subpopulations in a habitat-specific manner, accompanied by gradual separation of gene pools as evidenced by increased habitat specificity of the most recent recombinations. These findings reconcile previous, seemingly contradictory empirical observations of the genetic structure of bacterial populations and point to a more unified process of differentiation in bacteria and sexual eukaryotes than previously thought.en_US
dc.description.sponsorshipNational Science Foundation (U.S.) (Grant DEB-0918333)en_US
dc.description.sponsorshipWoods Hole Center for Oceans & Human Healthen_US
dc.description.sponsorshipGordon and Betty Moore Foundationen_US
dc.description.sponsorshipUnited States. Dept. of Energy. Genomes To Lifeen_US
dc.language.isoen_US
dc.publisherAmerican Association for the Advancement of Science (AAAS)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1126/science.1218198en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titlePopulation Genomics of Early Events in the Ecological Differentiation of Bacteriaen_US
dc.typeArticleen_US
dc.identifier.citationShapiro, B. J., et al. "Population Genomics of Early Events in the Ecological Differentiation of Bacteria." Science 6 April 2012: Vol. 336 no. 6077 pp. 48-51.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Civil and Environmental Engineeringen_US
dc.contributor.mitauthorCordero Sanchez, Otto Xavieren_US
dc.contributor.mitauthorPreheim, Sarah Pacochaen_US
dc.contributor.mitauthorTimberlake, Sonia Cragoen_US
dc.contributor.mitauthorSzabo, Gittaen_US
dc.contributor.mitauthorPolz, Martin F.en_US
dc.contributor.mitauthorAlm, Eric J.en_US
dc.relation.journalScienceen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsShapiro, B. J.; Friedman, J.; Cordero, O. X.; Preheim, S. P.; Timberlake, S. C.; Szabo, G.; Polz, M. F.; Alm, E. J.en_US
dc.identifier.orcidhttps://orcid.org/0000-0001-8294-9364
dc.identifier.orcidhttps://orcid.org/0000-0001-9296-3733
mit.licenseOPEN_ACCESS_POLICYen_US


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