Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments
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Microfluidic devices allow for precise control of the cellular and noncellular microenvironment at physiologically relevant length- and time-scales. These devices have been shown to mimic the complex in vivo microenvironment better than conventional in vitroassays, and allow real-time monitoring of homotypic or heterotypic cellularinteractions.Microfluidic culture platforms enable new assay designs for culturing multiple different cell populations and/or tissue specimens under controlled user-defined conditions. Applications include fundamental studies of cell population behaviors, high-throughput drug screening, and tissue engineering. In this review, we summarize recent developments in this field along with studies of heterotypic cell-cell interactions and tissue specimen culture in microfluidic devices from our own laboratory.
Date issued
2011-03Department
Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Mechanical EngineeringJournal
Biomicrofluidics
Publisher
American Institute of Physics (AIP)
Citation
Zervantonakis, Ioannis K., Chandrasekhar R. Kothapalli, Seok Chung, Ryo Sudo, and Roger D. Kamm. “Microfluidic Devices for Studying Heterotypic Cell-Cell Interactions and Tissue Specimen Cultures Under Controlled Microenvironments.” Biomicrofluidics 5, no. 1 (2011): 013406. © 2011 American Institute of Physics
Version: Final published version
ISSN
19321058