dc.contributor.author | Zervantonakis, Ioannis K. | |
dc.contributor.author | Kothapalli, Chandrasekhar R. | |
dc.contributor.author | Chung, Seok | |
dc.contributor.author | Sudo, Ryo | |
dc.contributor.author | Kamm, Roger Dale | |
dc.date.accessioned | 2014-09-09T16:07:14Z | |
dc.date.available | 2014-09-09T16:07:14Z | |
dc.date.issued | 2011-03 | |
dc.date.submitted | 2010-09 | |
dc.identifier.issn | 19321058 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/89232 | |
dc.description.abstract | Microfluidic devices allow for precise control of the cellular and noncellular microenvironment at physiologically relevant length- and time-scales. These devices have been shown to mimic the complex in vivo microenvironment better than conventional in vitroassays, and allow real-time monitoring of homotypic or heterotypic cellularinteractions.Microfluidic culture platforms enable new assay designs for culturing multiple different cell populations and/or tissue specimens under controlled user-defined conditions. Applications include fundamental studies of cell population behaviors, high-throughput drug screening, and tissue engineering. In this review, we summarize recent developments in this field along with studies of heterotypic cell-cell interactions and tissue specimen culture in microfluidic devices from our own laboratory. | en_US |
dc.description.sponsorship | National Science Foundation (U.S.) (Grant EFRI-0735997) | en_US |
dc.description.sponsorship | IR&D Project DL-H-550151 | en_US |
dc.description.sponsorship | Charles Stark Draper Laboratory | en_US |
dc.description.sponsorship | Singapore-MIT Alliance for Research and Technology | en_US |
dc.description.sponsorship | National Institute for Biomedical Imaging and Bioengineering (U.S.) (Grant EB003805) | en_US |
dc.language.iso | en_US | |
dc.publisher | American Institute of Physics (AIP) | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1063/1.3553237 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | PMC | en_US |
dc.title | Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Zervantonakis, Ioannis K., Chandrasekhar R. Kothapalli, Seok Chung, Ryo Sudo, and Roger D. Kamm. “Microfluidic Devices for Studying Heterotypic Cell-Cell Interactions and Tissue Specimen Cultures Under Controlled Microenvironments.” Biomicrofluidics 5, no. 1 (2011): 013406. © 2011 American Institute of Physics | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Mechanical Engineering | en_US |
dc.contributor.mitauthor | Zervantonakis, Ioannis K. | en_US |
dc.contributor.mitauthor | Kothapalli, Chandrasekhar R. | en_US |
dc.contributor.mitauthor | Kamm, Roger Dale | en_US |
dc.relation.journal | Biomicrofluidics | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Zervantonakis, Ioannis K.; Kothapalli, Chandrasekhar R.; Chung, Seok; Sudo, Ryo; Kamm, Roger D. | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-7232-304X | |
mit.license | PUBLISHER_POLICY | en_US |
mit.metadata.status | Complete | |