Dopamine modulation of learning and memory in the prefrontal cortex: insights from studies in primates, rodents, and birds
Author(s)Puig, M. Victoria; Rose, Jonas; Schmidt, Robert; Freund, Nadja
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In this review, we provide a brief overview over the current knowledge about the role of dopamine transmission in the prefrontal cortex during learning and memory. We discuss work in humans, monkeys, rats, and birds in order to provide a basis for comparison across species that might help identify crucial features and constraints of the dopaminergic system in executive function. Computational models of dopamine function are introduced to provide a framework for such a comparison. We also provide a brief evolutionary perspective showing that the dopaminergic system is highly preserved across mammals. Even birds, following a largely independent evolution of higher cognitive abilities, have evolved a comparable dopaminergic system. Finally, we discuss the unique advantages and challenges of using different animal models for advancing our understanding of dopamine function in the healthy and diseased brain.
DepartmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciences; Picower Institute for Learning and Memory
Frontiers in Neural Circuits
Frontiers Research Foundation
Puig, M. Victoria, Jonas Rose, Robert Schmidt, and Nadja Freund. “Dopamine Modulation of Learning and Memory in the Prefrontal Cortex: Insights from Studies in Primates, Rodents, and Birds.” Front. Neural Circuits. 8 (August 5, 2014).
Final published version