dc.contributor.author | Hook, Andrew L. | |
dc.contributor.author | Chang, Chien-Yi | |
dc.contributor.author | Yang, Jing | |
dc.contributor.author | Luckett, Jeni | |
dc.contributor.author | Cockayne, Alan | |
dc.contributor.author | Atkinson, Steve | |
dc.contributor.author | Mei, Ying | |
dc.contributor.author | Bayston, Roger | |
dc.contributor.author | Irvine, Derek J. | |
dc.contributor.author | Williams, Paul | |
dc.contributor.author | Davies, Martyn C. | |
dc.contributor.author | Alexander, Morgan R. | |
dc.contributor.author | Anderson, Daniel Griffith | |
dc.contributor.author | Langer, Robert S | |
dc.date.accessioned | 2014-10-21T19:17:52Z | |
dc.date.available | 2014-10-21T19:17:52Z | |
dc.date.issued | 2012-08 | |
dc.date.submitted | 2012-06 | |
dc.identifier.issn | 1087-0156 | |
dc.identifier.issn | 1546-1696 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/91141 | |
dc.description.abstract | Bacterial attachment and subsequent biofilm formation pose key challenges to the optimal performance of medical devices. In this study, we determined the attachment of selected bacterial species to hundreds of polymeric materials in a high-throughput microarray format. Using this method, we identified a group of structurally related materials comprising ester and cyclic hydrocarbon moieties that substantially reduced the attachment of pathogenic bacteria (Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli). Coating silicone with these 'hit' materials achieved up to a 30-fold (96.7%) reduction in the surface area covered by bacteria compared with a commercial silver hydrogel coating in vitro, and the same material coatings were effective at reducing bacterial attachment in vivo in a mouse implant infection model. These polymers represent a class of materials that reduce the attachment of bacteria that could not have been predicted to have this property from the current understanding of bacteria-surface interactions. | en_US |
dc.language.iso | en_US | |
dc.publisher | Nature Publishing Group | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1038/nbt.2316 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | PMC | en_US |
dc.title | Combinatorial discovery of polymers resistant to bacterial attachment | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Hook, Andrew L, Chien-Yi Chang, Jing Yang, Jeni Luckett, Alan Cockayne, Steve Atkinson, Ying Mei, et al. “Combinatorial Discovery of Polymers Resistant to Bacterial Attachment.” Nature Biotechnology 30, no. 9 (August 12, 2012): 868–875. | en_US |
dc.contributor.department | Harvard University--MIT Division of Health Sciences and Technology | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Chemical Engineering | en_US |
dc.contributor.department | Koch Institute for Integrative Cancer Research at MIT | en_US |
dc.contributor.mitauthor | Mei, Ying | en_US |
dc.contributor.mitauthor | Langer, Robert | en_US |
dc.contributor.mitauthor | Anderson, Daniel Griffith | en_US |
dc.relation.journal | Nature Biotechnology | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Hook, Andrew L; Chang, Chien-Yi; Yang, Jing; Luckett, Jeni; Cockayne, Alan; Atkinson, Steve; Mei, Ying; Bayston, Roger; Irvine, Derek J; Langer, Robert; Anderson, Daniel G; Williams, Paul; Davies, Martyn C; Alexander, Morgan R | en_US |
dc.identifier.orcid | https://orcid.org/0000-0001-5629-4798 | |
dc.identifier.orcid | https://orcid.org/0000-0003-4255-0492 | |
mit.license | PUBLISHER_POLICY | en_US |
mit.metadata.status | Complete | |