Core-Shell Hydrogel Microcapsules for Improved Islets Encapsulation

Author(s)
Ma, Minglin; Chiu, Alan; Sahay, Gaurav; Doloff, Joshua C.; Dholakia, Nimit; ... Show more
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Abstract
Islets microencapsulation holds great promise to treat type 1 diabetes. Currently used alginate microcapsules often have islets protruding outside capsules, leading to inadequate immuno-protection. A novel design of microcapsules with core–shell structures using a two-fluid co-axial electro-jetting is reported. Improved encapsulation and diabetes correction is achieved in a single step by simply confining the islets in the core region of the capsules.
Date issued
2013-05
URI
http://hdl.handle.net/1721.1/91236
Department
Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Chemical Engineering; Koch Institute for Integrative Cancer Research at MIT
Journal
Advanced Healthcare Materials
Publisher
Wiley-VCH Verlag GmbH & Co.
Citation
Ma, Minglin, Alan Chiu, Gaurav Sahay, Joshua C. Doloff, Nimit Dholakia, Raj Thakrar, Joshua Cohen, et al. “Core-Shell Hydrogel Microcapsules for Improved Islets Encapsulation.” Advanced Healthcare Materials 2, no. 5 (December 3, 2012): 667–672.
Version: Author's final manuscript
ISSN
21922640
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