Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability
Author(s)Eltoukhy, Ahmed A.; Chen, Delai; Alabi, Christopher A.; Anderson, Daniel Griffith; Langer, Robert S
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Degradable, cationic poly(β-amino ester)s (PBAEs) with alkyl side chains are developed for non-viral gene delivery. Nanoparticles formed from these PBAE terpolymers exhibit significantly enhanced DNA transfection potency and resistance to aggregation. These hydrophobic PBAE terpolymers, but not PBAEs lacking alkyl side chains, support interaction with PEG-lipid conjugates, facilitating their functionalization with shielding and targeting moieties and accelerating the in vivo translation of these materials.
DepartmentHarvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Chemical Engineering; Koch Institute for Integrative Cancer Research at MIT
Wiley-VCH Verlag GmbH & Co.
Eltoukhy, Ahmed A., Delai Chen, Christopher A. Alabi, Robert Langer, and Daniel G. Anderson. “Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability.” Advanced Materials 25, no. 10 (January 4, 2013): 1487–1493.
Author's final manuscript