Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability

Author(s)
Eltoukhy, Ahmed A.; Chen, Delai; Alabi, Christopher A.; Anderson, Daniel Griffith; Langer, Robert S
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Abstract
Degradable, cationic poly(β-amino ester)s (PBAEs) with alkyl side chains are developed for non-viral gene delivery. Nanoparticles formed from these PBAE terpolymers exhibit significantly enhanced DNA transfection potency and resistance to aggregation. These hydrophobic PBAE terpolymers, but not PBAEs lacking alkyl side chains, support interaction with PEG-lipid conjugates, facilitating their functionalization with shielding and targeting moieties and accelerating the in vivo translation of these materials.
Date issued
2013-03
URI
http://hdl.handle.net/1721.1/91242
Department
Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Chemical Engineering; Koch Institute for Integrative Cancer Research at MIT
Journal
Advanced Materials
Publisher
Wiley-VCH Verlag GmbH & Co.
Citation
Eltoukhy, Ahmed A., Delai Chen, Christopher A. Alabi, Robert Langer, and Daniel G. Anderson. “Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability.” Advanced Materials 25, no. 10 (January 4, 2013): 1487–1493.
Version: Author's final manuscript
ISSN
09359648
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