| dc.contributor.author | Eltoukhy, Ahmed A. | |
| dc.contributor.author | Chen, Delai | |
| dc.contributor.author | Alabi, Christopher A. | |
| dc.contributor.author | Anderson, Daniel Griffith | |
| dc.contributor.author | Langer, Robert S | |
| dc.date.accessioned | 2014-10-30T19:05:13Z | |
| dc.date.available | 2014-10-30T19:05:13Z | |
| dc.date.issued | 2013-03 | |
| dc.date.submitted | 2012-11 | |
| dc.identifier.issn | 09359648 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/91242 | |
| dc.description.abstract | Degradable, cationic poly(β-amino ester)s (PBAEs) with alkyl side chains are developed for non-viral gene delivery. Nanoparticles formed from these PBAE terpolymers exhibit significantly enhanced DNA transfection potency and resistance to aggregation. These hydrophobic PBAE terpolymers, but not PBAEs lacking alkyl side chains, support interaction with PEG-lipid conjugates, facilitating their functionalization with shielding and targeting moieties and accelerating the in vivo translation of these materials. | en_US |
| dc.description.sponsorship | National Heart, Lung, and Blood Institute | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Program of Excellence in Nanotechnology (PEN) Award, Contract #HHSN268201000045C) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (NIH Grant R01-EB000244-27) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (NIH Grant 5-R01-CA132091-04) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (NIH Grant R01-DE016516-03) | en_US |
| dc.description.sponsorship | National Science Foundation (U.S.) (Graduate Research Fellowship) | en_US |
| dc.description.sponsorship | Juvenile Diabetes Research Foundation International (Grant 17–2007-1063) | en_US |
| dc.language.iso | en_US | |
| dc.publisher | Wiley-VCH Verlag GmbH & Co. | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1002/adma.201204346 | en_US |
| dc.rights | Creative Commons Attribution-Noncommercial-Share Alike | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | en_US |
| dc.source | PMC | en_US |
| dc.title | Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Eltoukhy, Ahmed A., Delai Chen, Christopher A. Alabi, Robert Langer, and Daniel G. Anderson. “Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability.” Advanced Materials 25, no. 10 (January 4, 2013): 1487–1493. | en_US |
| dc.contributor.department | Harvard University--MIT Division of Health Sciences and Technology | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemical Engineering | en_US |
| dc.contributor.department | Koch Institute for Integrative Cancer Research at MIT | en_US |
| dc.contributor.mitauthor | Eltoukhy, Ahmed A. | en_US |
| dc.contributor.mitauthor | Chen, Delai | en_US |
| dc.contributor.mitauthor | Langer, Robert | en_US |
| dc.contributor.mitauthor | Anderson, Daniel Griffith | en_US |
| dc.relation.journal | Advanced Materials | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Eltoukhy, Ahmed A.; Chen, Delai; Alabi, Christopher A.; Langer, Robert; Anderson, Daniel G. | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0001-5629-4798 | |
| dc.identifier.orcid | https://orcid.org/0000-0003-4255-0492 | |
| mit.license | OPEN_ACCESS_POLICY | en_US |
| mit.metadata.status | Complete | |
